BACKGROUND We recently constructed a Bacillus subtilis strain (CCTCC M 2016536) from which we had deleted the srfC, spoIIAC, nprE, aprE and amyE genes. This strain is capable of robust recombinant protein production and amenable to high-cell-density fermentation. Because the promoter is among the factors that influence the production of target proteins, optimization of the initial promoter, Pam...

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introduction: cryptorchidism has been proved to cause apoptosis in germ cells in respond to changes in the stimulation levels of specific physiological events. the purpose of this study was to determine whether treatment of bilateral cryptorchidism was associated with alterations in testicular gene expression. methods: to induce bilateral cryptorchid model, immature mice were anesthetized and a...

idiopathic chronic urticaria (icu), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. it is speculated that the promoter polymorphism of tgf-β1 gene may be involved in icu. this condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. a total of 40 patients with icu and 41 normal subjects were studie...

Background Patients with SLE are recommended to continue the maintenance therapy as less glucocorticoid possible.1) However, tapering often results in recurrence of SLE. Current reports suggested that adding BEL standard could lead reduction and SLE.2) Objectives The aim this study is evaluate efficacy safety co-treatment Methods Fourteen patients receiving were enrolled study. Dose prednisolon...

INTRODUCCIÓN. El programa de movilidad académica Erasmus ya ha cumplido 30 años des-de su puesta en marcha (1987). Con una imagen éxito tanto cifras como aportación al fortalecimiento ciudadanía europea, se convertido un referente para cualquier universitario. La aceptación popular efecto positivo contrasta con el reducido número investigaciones empíricas que comprueban si este realmente contri...

identification of genes with invariant levels of gene expression is a prerequisite for validating transcriptomicchanges accompanying development. ideally expression of these genes should be independent of themorphogenetic process or environmental condition.we report here the validation of internal control genei.e.tps (trehalose 6-phosphate-synthase) in cotton (gossypium spp), using taqman syste...

In this paper we bring to bear some new tools from statistical learning on the analysis of roll call data. We present a new data-driven model for roll call voting that is geometric in nature. We construct the model by adapting the “Partition Decoupling Method,” an unsupervised learning technique originally developed for the analysis of families of time series, to produce a multiscale geometric ...