The post methods era has witnessed a dramatic change inapproaches to and methods of teaching as well as testing. At the heart of such a change, collaborative learning has received top priority and testing domain has actually gone under scrutiny. This new mode of education has made stakeholders, especially in higher education; reflect on an interactive e-assessment based instruction. Such a cybe...

In several pedigrees of early onset familial Alzheimer's disease (FAD), point mutations in the beta-amyloid precursor protein (APP) gene are genetically linked to the disease. This finding implicates APP in the pathogenesis of Alzheimer's disease in these individuals. To understand the in vivo function of APP and its processing, we have generated an APP-null mutation in mice. Homozygous APP-def...

several normal and neoplastic mouse tissues. APP is rapidly cleared from the peritoneal fluid and blood after intraperitoneal or intravenous administration. The drug is taken up by the blood cells and is lost from them less rapidly than from serum. Approximately one-half of the administered drug is excreted in the urine from nor mal mice in 24 hours, and one-half of this is within the 1st hour....

The phosphorylation of Amyloid Precursor Protein (APP) at Thr668 plays a key role in APP metabolism that is highly relevant to AD. The c-Jun-N-terminal kinase (JNK), glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinase 5 (Cdk5) can all be responsible for this phosphorylation. These kinases are activated by excitotoxic stimuli fundamental hallmarks of AD. The exposure of cortical neu...

Nowadays everyone is using smart phone. Many applications are in smart phone. To download an application user visit App store such as Google play store, Apple play store etc, then he or she is able to see the different application lists. User has no awareness about the application. So user looks at the list and download the application from App Store based on the mobile app rank. App developers...

Amyloid precursor protein (APP) plays a pivotal role in Alzheimer's disease (AD) pathogenesis, but its normal physiological functions are less clear. Combined deletion of the APP and APP-like protein 2 (APLP2) genes in mice results in post-natal lethality, suggesting that APP performs an essential, if redundant, function during embryogenesis. We previously showed that injection of antisense mor...

OBJECTIVES This study was conducted to develop a smartphone application (app) as an educational learning instrument for coronary artery disease (CAD) patients and to assess the users' level of satisfaction. METHODS This methodological research involves elicited learning content for CAD patients to develop a learning instrument using the smartphone app. The app was developed according to the s...

The amyloid precursor protein (APP) undergoes a variety of modifications through enzymatic cleavage leading to the formation of pro-Alzheimer’s disease (AD) and anti-AD biologically active peptides. One such cleavage product, APP ΔC31 results from the caspase cleavage of the full length APP protein (APP695) at amino acid Asp664 as well as the concomitant formation of the 31 amino acid C-termina...

Activated platelets release a potent inhibitor of factor XIa previously identified as a Kunitz proteinase inhibitor domain-containing form of the beta-amyloid precursor proteins (beta APP). Two carboxy-terminal truncated forms of the beta APP, beta APP-751 and beta APP-770, are shown to be the predominant isoforms secreted by platelets. The release of beta APP from platelets is responsible for ...

Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still poorly understood. We previously showed that GABAergic short-term plasticity is impaired in App knock-out (App-/-) animals, but the precise mechanism by which APP regulates GABAergic synaptic transmission has remained elusive. Using electrophysiological, biochemical, moleculobiological, and pharmacolo...