Abstract Background Glioma is a complex cancer with high morbidity and mortality. Bone marrow mesenchymal stem cells (BMSCs) have shown promise as an excellent cell/drug delivery vehicle for gene-targeted therapy; however, maintaining genetic stability biological activity remains difficult. Furthermore, whether BMSCs support or inhibit tumor growth debated. This study investigated traditional C...

There is still no clarity on whether the endonuclease incisions in apoptotic cells are induced randomly in the genome or induced in some preferable sites. In order to evaluate the intensity of DNA fragmentation in the chicken alpha-globin domain, AEV-virus transformed chicken erythroblasts (HD3) were incubated in a serum free medium, and their DNA was Southern blotted and hybridised with probes...

The gene BCL2L2 encoding protein BCL2-like 2, alias BCL-W is involved in regulation of programmed cell death. It represents a member of the BCL-2 gene family comprising nearly 20 proteins, which govern the mitochondria-dependent pathway for apoptosis (Reed, 2000). BCL2-like 2 belongs to the subfamily of anti-apoptotic proteins (Denisov et al., 2003). Enforced expression of BCL2L2 in human lymph...

different treatment strategies of alzheimer's disease (ad) are being studied for treating or slowing the progression of ad. many pharmaceutically important regulation systems operate through proteins as drug targets. here, we investigate the drug target proteins in beta-amyloid (aβ) injected rat hippocampus treated with lavandula angustifolia (la) by proteomics techniques. the reported stu...

During neuronal latency of herpes simplex virus (HSV)-1, the latency-associated transcript (LAT) is the only viral gene readily detectable. LAT is required for the high-level reactivation phenotype in animal models. LAT's anti-apoptotic activity was recently demonstrated by our group and it was proposed that LAT's anti-apoptotic function is involved in enhancing the reactivation phenotype. Rece...

objective: breast cancer is the second leading cause of cancer death in women. cisplatin is a traditional cancer drug commonly used in chemotherapy for killing cancer cells. modulation at the mrna levels of apoptotic related genes often correlate with the sensitivity of various types of cancer cells to chemotherapeutic agents. nanoparticulate drug delivery systems are being developed to effecti...

Cytochrome c (Cyt. c) is a key initiator of the caspases that activate cell apoptosis. The spatiotemporal evaluation contents Cyt. in cellular compartments and detection delivery between upon apoptosis important for probing viabilities. We introduce an optical probe electrochemical quantitative assessment at single level. or probes are functionalized with photoresponsive o-nitrobenzylphosphate ...