a three month-old-male red deer calf (cervus elaphus maral) was examined post mortem for the cause of death in arasbaran preserved area in east azerbaijan in september 2006. the main history of the case was the lack of colostrum intake after birth. the necropsy 6 hours after death, revealed severe general congestion especially in lungs and visceral organs (liver and jejunum). the cut surface of...

Background: Tumor radioresistance leads to a reduction in the efficiency of radiation therapy. It is very important to explore the cellular mechanisms leading to radioresistance and to find potential therapeutic targets, which might improve the efficacy of radiation therapy. This study was to investigate the role of ataxia-telangiectasia mutated (ATM) and murine double minute X (MDMX) in radior...

   Cromolyn sodium, a mast cell stabilizing agent, provides an immediate protective effect against the exercise-induced bronchoconstriction while being used before the exercise. However, cromolyn is ineffective in reversing asthmatic bronchospasm; it is used as a maintenance therapy and has a prophylactic role in chronic asthma.    The purpose of this study was to determine the extent of change...

Abstract Innate lymphoid cells (ILCs) are sentinels of healthy organ function, yet it is unknown how ILCs adapt to distinct anatomical niches within tissues. Here, we used a unique humanized mouse model, MISTRG mice transplanted with human hematopoietic stem and progenitor (HSPCs), define the gene signatures in vascular versus tissue (extravascular) compartment lung. Single-cell RNA-sequencing ...

Abstract Development of universal influenza (flu) vaccines requires better knowledge lung-resident immune responses. That includes flu-specific CD4 T cells, which establish long-term lung residency and induce a diversified local protective response to subsequent infection. Tissue-resident helper (Trh) cells are subset that share phenotypic functional features with follicular (Tfh). Trh serve am...

hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. recent research has increased our understanding of this pathway and its relation to other signalling pathways. in addition, a large number of studies confirmed the alterati...

objective: sulfur mustard (sm) is a potent mutagenic agent that targets several organs, particularly lung tissue. changes in morphological structure of the airway system are associated with chronic obstructive pulmonary deficiency following exposure to sm. although numerous studies have demonstrated pathological effects of sm on respiratory organs, unfortunately there is no effective treatment ...

background the attention of the scientific community has been recently focused on the role of tumor-infiltrating lymphocytes in non-small-cell cancer and there is a convergence of results, supporting a direct proportionality between lymphocytic infiltrate and good prognosis. objectives the aim of our research was to investigate the immune response around and inside the small-cell lung neoplasti...

Introduction: Little is known about long-term survivors after complete resection of non-small cell lung cancer. Therefore, this study clarified the characteristics 10-year-plus postoperative with recurrence.

Background: Our study aimed to establish a clinically practical and reliable prognostic nomogram based on the important factors predict prognosis of patients with lung metastatic renal cell carcinoma (RCC).