apoptosis has a critical role in the pathogenesis of bleomycin induced-pulmonary fibrosis. the severity of fibrosis varies among different strains of mice. recent studies have indicated that expression of apoptotic regulatory genes may be specific in different cell types in various strains. in this study, bleomycin-induced pulmonary apoptosis in nmri albino mice were compared with c57bl/6 black...

An 8 weeks trial was performed to test the effects of light spectra [full-spectrum, violet (405 nm), blue (470 cyan (500 green (525 yellow (570 and red (625 nm)] on growth performance, molting, antioxidant capacity, stress response expression apoptosis-related genes in Scylla paramamosain . Results showed that spectrum had a significant effect S. physiology. Compared light, crabs exposed signif...

The possibility of modifying apoptosis-related genes in tumor cells is an interesting line of research that calls for multidisciplinary experimentation to describe its characteristics and the conditions required. In vitro low doses of alpha particle irradiation due to radon have an antiproliferative effect on the growth of MCF-7 cells and increase the sensibility of cancer cells to taxol, a che...

Hepatic dysfunction is a feature of dengue virus (DENV) infection. Hepatic biopsy specimens obtained from fatal cases of DENV infection show apoptosis, which relates to the pathogenesis of DENV infection. However, how DENV induced liver injury is not fully understood. In this study, we aim to identify the factors that influence cell death by employing an apoptosis-related siRNA library screenin...

BACKGROUND/AIMS Helicobacter pylori induces the apoptosis of gastric epithelial cells in vivo and in vitro. However, the molecular mechanism has not been clarified. The aim of this study was to investigate the effect of H pylori on the apoptosis of gastric epithelial cells and the expression of apoptosis related genes in vitro. METHODS Human gastric adenocarcinoma SGC-7901 cells were co-cultu...

Abstract Background Alcohol-induced intestinal dysbiosis disrupts and inflammatory responses are essential in the development of alcoholic fatty liver disease (AFLD). Here, we investigated effects Fmo5 on changes enteric microbiome composition a model AFLD dissected pathogenic role AFLD-induced pathology. Methods The expression profile data GSE8006 GSE40334 datasets were downloaded from GEO dat...

Threatened abortion (TA) is the most common complication in early pregnancy and caused by anxiety depressive symptoms. The Zishen Yutai Pill (ZYP) a traditional herbal formula that commonly used to treat TA. However, pharmacological mechanisms underlying effect of ZYP have yet be elucidated. To disclose mechanism treatment TA, first, we identified chemical constituents from multiple databases t...

Parthenolide is a secondary metabolite, which naturally occurs in the feverfew plant and is responsible for its healing power. The potential of parthenolide in inhibition of cancer cell growth, alone or in combination with other anti-cancer therapeutics, have been studied in several laboratories. In this study, the effect of extracted parthenolide on the expression of seven pro-apoptotic genes,...