apolipoprotein B-100 in 12 subjects and their kindred. Eur J Clin Chem Clin Biochem 1992;30:729–36. 21. Kotze MJ, Peeters AV, Langenhoven E, Wauters JG, Van Gaal LF. Phenotypic expression and frequency of familial defective apolipoprotein B-100 in Belgian hypercholesterolemics. Atherosclerosis 1994;111:217–25. 22. Pimstone SN, Defesche JC, Clee SM, Bakker HD, Hayden MR, Kastelein JJ. Difference...

Familial combined hyperlipidemia (FCHL) is a common inherited lipid disorder, affecting 1 to 2 percent of the population in Westernized societies. Individuals with FCHL have large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) and develop premature coronary heart disease. A mouse model displaying some of the features of FCHL was created by crossing mice carr...

background: nonalcoholic fatty liver disease (nafld) is the most common chronic liver disease in the world. oral administration of symbiotic and vitamin e has been proposed as an effective treatment in nafld patients. this study was carried out to assess the effects of symbiotic and/or vitamin e supplementation on liver enzymes, leptin, lipid profile, and some parameters of insulin resistance (...

The apo C-II gene from a patient with apo C-II deficiency has been sequenced after amplification by the polymerase chain reaction. A substitution of an adenosine for a guanosine at position 3002 in exon 3 of the patient's gene was identified by sequence analysis. This mutation leads to the introduction of a premature termination codon (TAA) at a position corresponding to amino acid 37 of mature...

1 Tikkanen MJ. Immunogenetic polymorphism of apolipoprotein B in man. Studies with a monoclonal anti-Ag(c) antibody. Am HeartJ 1987;113:462-7. 2 Viikari J, Akerblom HK, Nikkari T, et al. Atherosclerosis precursors in Finnish children and adolescents. IV. Serum lipids in newborns, children and adolescents. Acta Paediatr Scand 1985;318 (suppl): 103-9. 3 Berg K. DNA polymorphism at the apolipoprot...

Objective—We measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C) differed in their efflux capacity. Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I). Methods and Results—To understand why sera with si...

OBJECTIVE We measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C) differed in their efflux capacity. Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I). METHODS AND RESULTS To understand why sera with ...

A new method for low density lipoprotein (LDL) (d 1.019-1.063 g/ml)-apolipoprotein B (apoB) determination has been developed, based on the fact that very low density and intermediate density lipoproteins (VLDL and IDL) contain apolipoprotein C-I (apoC-I), whereas this apolipoprotein is apparently absent in LDL. VLDL and IDL were quantitatively precipitated with a monospecific anti-apoC-I antibo...

OBJECTIVES To assess the relationship between non-classical cardiovascular (CV) risk factors including non-HDL cholesterol (non-HDL-C), apolipoprotein B, triglycerides to HDL ratio, LDL size, inflammation or oxidative stress parameters and carotid intima-media thickness (CIMT), in order to better identify prevention or therapeutic targets. In addition, we studied the relationship between metabo...