Although several alleles of susceptibility to Alzheimer's disease (AD) have been studied in the last decades, few polymorphisms have been considered as risk factors for the disease. Among them, the APOE-e4 allele appears to be the major genetic risk factor for the onset of the disease. However, it is important to confirm the potential susceptibility of these genetic variants in different popula...

Background and Aims: Alzheimer's disease (AD) is the most common and devastating neurodegenerative disease of the elderly. Several studies indicated a relationship between different genes and AD. Bleomycin hydrolase (BLMH) and the Apolipoprotein E (ApoE) gene allele epsilon4 (E4) known as genetic risk factors for late-onset AD in sporadic cases. We have analyzed the association between the Apo ...

A polipoprotein E (apoE) has effects on lipoprotein metabolism and the vasculature that have long been considered to be anti-atherogenic [1]. In the plasma, apoE is found on the surface of triglyceride-rich lipoproteins, such as very low density lipoproteins (VLDL) and remnant particles. ApoE is also found on high density lipoproteins (HDL) and as such may serve distinct functions depending on ...

The present study aimed to investigate the effect of genetic polymorphisms of catechol-O-methyl transferase (COMT), apolipoprotein E (APOE), and brain derived neurotrophic factor (BDNF) on the modulation of the chemotherapy-induced cognitive impairment (CICI) in breast cancer patients. Eighty triple negative breast cancer (TNBC) and 165 non-triple negative breast cancer (NTNBC) patients were se...

In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects with EH of Chinese Hui ethnicity using polymerase chain reaction-restriction f...

BACKGROUND Recently, genetic variants of the neuronal sortilin-related receptor with A-type repeats (SORL1, also called LR11 or sorLA) have emerged as risk factors for the development of Alzheimer's disease (AD). METHODS In this study, SORL1 gene polymorphisms, which have been shown to be related to AD, were analyzed for associations with cerebrospinal fluid (CSF) amyloid beta1-42 (Aβ(1-42)),...

BACKGROUND Genetic variation in the estrogen receptor (ESR) may be associated with the incidence of Alzheimer's disease (AD), but this association could be modified by genetic and environmental factors. METHODS The association between five ESR α (ESR1) and β (ESR2) polymorphisms with 7-year dementia incidence was examined among 6959 older men and women from the Three City Study using multivar...

BACKGROUND Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late-onset Alzheimer disease (LOAD). The linkage disequilibrium pattern around the APOE gene has made it difficult to determine whether all the association signal is derived from APOE or whether there is an independent signal from a nearby gene. OBJECTIVE To attempt to replicate a recently reporte...

background : apolipoprotein e (apoe) gene encodes an important protein in reforming injuries of central nervous system (cns). it is assumed that various apoe alleles may be functionally different. the purpose of this study was to investigate the distribution of apoe genotypes in multiple sclerosis (ms) patients in a small cohort of iranians. methods : in this case-control study, blood samples o...