G. Ma, B. S. Levine, D. J. Lavrich Merck & Co., Inc. Purpose Amorphous solid dispersions have been increasingly used to enhance the bioavailability for poorly soluble drugs. Dissolution method development for these formulations has faced challenges due to their unstable super saturation state in aqueous media. Whether the dissolution sink condition should be based on API crystalline solubility ...

Networked applications interact with the TCP/IP stack through the socket API. Over the years, various extensions have been added to this popular API. In this paper, we propose and implement the TCPSnitch software that tracks the interactions between Linux and Android applications and the TCP/IP stack. We collect a dataset containing the interactions produced by more than 120 different applicati...

The range of a near-infrared (NIR) calibration model for tablet assay is extended using production “seed” spectra and synthetic spectra generated from placebos and “pure” API spectra. This method resolves the problem of not being able to obtain a range of production samples with +/15% of the label claim of API concentration online. A synthetic model is developed using five real production sampl...

The API ZYM system was compared with four anaerobe identification systems for the definitive identification of Clostridium difficile by using 88 cultures of C. difficile grown on Mueller-Hinton blood agar medium. The API ZYM system yielded a distinct and consistent enzyme profile for all test strains, whereas the sensitivities of the other systems in identifying C. difficile ranged from 78 to 9...

Developer forums contain opinions and information related to the usage of APIs. API names in forum posts are often not explicitly linked to their official resources. Automatic linking of an API mention to its official resources can be challenging for various reasons, such as, name overloading. We present a technique, ANACE, to automatically resolve API mentions in the textual contents of forum ...

We contend that a new networking API could better serve the needs of dataand service-oriented applications, and could more easily map to heterogeneous environments, than the pervasive Sockets API does. In this paper, we present an initial design of a networking API based on the publish/subscribe paradigm, along with an exploration of its security implications, examples to demonstrate several co...

The design of software should be made up of small packages and classes. The Java Standard API is now very large since Java’s beginnings, and contains over 200 packages, nearly 5800 classes, and nearly 50,000 methods. We have conducted visual software analysis on the Java Standard API using existing software visualization techniques to identify large packages and classes in the API. Our analysis...

In this paper we describe a persistent object store designed and implemented to test and evaluate the merits and shortcomings of the Java Reflection API. Our goal is to design a persistent object store that supports transparent object persistence. Our premise was that we should be able to achieve this goal if the reflection API is designed with enough features and flexibility. It turns out that...