OBJECTIVE To investigate the possible influence of follicular maturation and luteinization on anti-müllerian hormone (AMH) secretion and the relationship between per-follicle AMH levels, ovarian follicular status, and responsiveness to controlled ovarian hyperstimulation (COH). DESIGN Prospective study. SETTING University hospital in France. PATIENT(S) Thirty seven in vitro fertilization/...

UNLABELLED BACKGROUD/AIMS: Widely prescribed in routine practice, isotretinoin has an unknown impact on ovarian reserve. With a long history in acne treatment and numerous potential side effects, it is surprising that very few prospective studies have investigated its effect on ovarian reserve. Therefore, we aimed to evaluate the impact of oral isotretinoin on ovarian reserve based on hormonal ...

Age at first calving (AFC) affects the profitability of dairy enterprises. This study examined the relationships between AFC and subsequent fertility, milk production and survival up to third calving in UK Holstein-Friesian heifers; Study 1 comprised 134 consecutively born heifers from the same herd (AFC 764 ± 8 days) and Study 2 contained 445 heifers born on 17 farms (AFC 796 ± 6 days). Growth...

PURPOSE Vanishing Optotype letters have a pseudo high-pass design so that the mean luminance of the target is the same as the background and the letters thus 'vanish' soon after the resolution threshold is reached. We wished to determine the variability of acuity measurements using these letters compared to conventional letters, and in particular how acuity is affected by the number of alternat...

Ovarian follicles form through a process in which somatic pregranulosa cells encapsulate individual germ cells from germ cell syncytia. Complementary expression of the Notch ligand, Jagged1, in germ cells and the Notch receptor, Notch2, in pregranulosa cells suggests a role for Notch signaling in mediating cellular interactions during follicle assembly. Using a Notch reporter mouse, we demonstr...

The primary therapeutic goal for the oncology patient is survival. Recent advances in diagnoses and treatment of neoplasia have resulted in an ever-increasing number of patients being cured and resuming a normal life. However, recognized side effects of treatments used to eradicate malignancies are temporary or permanent sterility. The cryopreservation of ovarian tissue harvested before cancer ...

Activation of the RAS family of small G-proteins is essential for follicle stimulating hormone-induced signaling events and the regulation of target genes in cultured granulosa cells. To analyze the functions of RAS protein in granulosa cells during ovarian follicular development in vivo, we generated conditional knock-in mouse models in which the granulosa cells express a constitutively active...

OBJECTIVE To investigate the relationship between serum concentrations of inhibin A, inhibin B and estradiol (E(2)) and the number of developing follicles during the administration of exogenous follicle-stimulating hormone (FSH) in various regimens in normo-ovulatory volunteers and to evaluate if inhibins act as suitable markers for the number of developing follicles during ovarian stimulation....

Infertility is the inability to conceive following 1 year of unprotected intercourse in cases where the female is ≤35 years of age or following 6 months of unprotected intercourse for women >35 years of age. The female factor infertility is found in 40% of cases, the male in 20% of cases and the both male and female factors in 20% of cases. Female factors can further be divided into tubal (40%)...

Ovarian reserve (OR) screening of the general population is generally not advocated as it has not been conclusively established to reflect immediate potential for natural conception, while it may also potentially create anxiety for women. However, in this paper, we argue in support of screening of the general population for diminished OR. First, OR tests such as measurements of anti-Müllerian h...