expression of eukaryotic proteins in e. coli often results in their aggregation. proper folding and solubility of therapeutical proteins are the pre-requisite for their bioactivity. this is not achieved in cytoplasmic expression in e. coli because of the absence of disulfide bonds formation. a novel expression/secretion vector was constructed which exploited β-lactamase signal sequence to trans...

Erythromycin ophthalmic ointment (E. Fougera & Co., Melville, N.Y.) and erythromycin gluceptate standards prepared in ointment base were stored at room temperature and heated at temperatures up to 45 degrees C for as long as 6 h before being assayed for bioactivity. We were unable to detect any significant loss of antibiotic bioactivity.

Background: Mangrove ecosystems have been known to possess diverse secondary metabolites and a good number of bioactive compounds of pharmaceutical importance have been reported from the mangrove plants. They are biochemically unique, producing wide array of natural products with unique bioactivity. They possess active metabolites with some novel chemical structures which belong to diverse chem...

Secondary metabolite production is assumed to be costly and therefore the resource allocation to their production should be optimized with respect to primary biological functions such as growth or reproduction. Sponges are known to produce a great diversity of secondary metabolites with powerful biological activities that may explain their domination in some hard substrate communities both in t...

The injectable composites were formulated from melt-derived 45S5 bioactive glass powder and gum tragacanth. The effect of tragacanth concentration (2 and 4 w/v%) and powder to liquid ratio (P/L= 1.5 to 2.5) on rheological properties, injectability, degradation, swelling, and bioactivity the composites was studied. With the increase of P/L ratio and tragacanth concentration, the force requ...

The aim of this work was to investigate the effect of silica coating on bioactivity and biodegradability of hydroxyapatite. In this purpose, we firstly attempted to synthesis hydroxyapatite (HA) nanoparticles and its silica coated (Si-HA) sample in collagen matrix using calcium chloride, sodium phosphate and sodium silicate. Characterization of the sample was carried out using Fourier transform...

Marine compound database consists of marine natural products and chemical entities, collected from various literature sources, which are known to possess bioactivity against human diseases. The database is constructed using html code. The 12 categories of 182 compounds are provided with the source, compound name, 2-dimensional structure, bioactivity and clinical trial information. The database ...

The purpose of this paper is to create a resource for the future scientific study of the medical ethnobotany and bioactivity of pteridophytes on Moorea, French Polynesia. Pteridophytes comprise a small fraction of the Moorean pharmacopoeia; however they are a highly abundant resource on this tropical island. Compiled here are all the relevant data available on phytochemistry, bioactivity and me...

recent studies have indicated the profound  anti-tumor activity of artemisinin's compounds,  among  which;  arteether  is an  oil-soluble derivative of  artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. an experiment was carried out on tumor-bearing balb/c mice to estimate the effects of arteether  on  tumor  growth  and  antitumor  im...