The current study aimed to ascertain the impact of acute codeine dose (0.50 and 1 ml/ 250g), on histolopathological profile liver kidney in male rats. A synthetic antispasmodic substance with comparatively low toxicity is opioid derivatives (Codeine), In present results found that normal histological structure, except Some minor changes were shown control group (antihistamine syrup, which does ...

Baclofen is a synthetic derivative of GABA and used as muscle relaxant or antispasmodic agent. It in the management various spasticity resulting from conditions such cerebral palsy, spinal cord injuries, stroke. The reported potential adverse effects following overdose are marked impairment consciousness, acute kidney injury, seizures, coma, respiratory failure. Since there no specific antidote...