The drugs used for the relief of pain in the surgical sphere can conveniently be divided into potent and mild analgesics. The potent analgesics constitute essentially morphine and its semisynthetic and synthetic derivatives. The mild agents can be subdivided into those which are weak relations of the narcotic analgesics and those which possess antipyretic and anti-inflammatory in addition to an...

A double blind trial was conducted to determine the dose of ibuprofen suspension, which is effective in reducing the body temperature. The principal measure of efficacy was a reduction in axillary temperature of 1 degree C or more three hours after dosing. A second objective of the trial was to compare the incidence and severity of side effects and the palatability of a range of ibuprofen doses...

Both external cooling and pharmacotherapy have been used to treat fever since time immemorial. In the past century such treatments have proliferated at an astonishing rate. The COX-2 inhibitors are the most recent additions to the antipyretic pharmacopoeia. Additional research is needed to determine whether they represent an important new chapter in antipyretic therapy's long history or, for th...

INTRODUCTION Self-medication is an increasingly frequent phenomenon worldwide; some studies suggest that there is a relationship with socio-economic and cultural factors. OBJECTIVE To determine the prevalence of self-medication and its related factors in a Colombian city. MATERIALS AND METHODS Cross-sectional descriptive study, in Pereira, Colombia. We selected 414 adults using simple rando...

Psychological stress results in a rise in body temperature. Here we report that in rats, hyperthermia induced by open-field stress can be blocked by administration of the antipyretic drug sodium salicylate. These data suggest that this rise in body temperature is a true fever, perhaps mediated by prostaglandins.

OBJECTIVE To evaluate temperature changes in febrile children that received a single oral dose of ibuprofen (10 mg/kg), the dose recommended for high fever, or dipyrone (15 mg/kg), the dose recommended by the manufacturer, at 2, 3, 4, 5, 6, 7 and 8 hours after administration. METHODS This open-label randomized (1:1) controlled clinical tried enrolled 80 febrile boys and girls aged 6 months to...

Although night sweating is a common outpatient complaint medical, literature on this subject is scarce. Tuberculosis, brucellosis and lymphoma are diseases in which night sweating is a dominant symptom, but these are infrequently found to be the cause of night sweats in modern practice. While these diseases remain important diagnostic considerations in patients with night sweats, other diagnosi...

The importance of pyrimidine nucleus in the metabolism of neurone is well recognised. Several compounds which are intimately concerned wrth the essential life processes of the neurones such as vitamins, coenzymes and both RNA and DNA of the mitochondria and of the nuclei contain pyrimidine moiety. It is not surprising that quite a large number of central nervous system depressants are derived f...

Flupirtine is a nonopioid drug without antipyretic or antiphlogistic properties and with a favorable tolerability in humans. It constitutes a unique class within the group of nonsteroidal analgesics and displays a peculiar pharmacokinetic/dynamic profile that could have large potentialities of applications in the veterinary field. This review describes and evaluates the pharmacologic literature...

L-glutamine markedly suppressed the development of the gastric lesions induced by aspirin in pylorus-ligated rats. In non-ligated normal rats, aspirin was absorbed rapidly after administration and was maintained in the blood in high salicylate concentration thereafter. When aspirin was administered in combination with L-glutamine, the absorption of aspirin was at nearly the same level as when a...