BACKGROUND Postoperative pain after TKA is a major concern to patients. The best technique to control pain is still controversial. Intrathecal morphine or periarticular multimodal drug injection are both commonly used and both appear to provide better pain control than placebo, but it is unclear whether one or the other provides better pain control. QUESTIONS/PURPOSES We asked whether intrath...

Topically applied aspirin has recently been reported to decrease histamine-induced itch in human volunteers. Our aim is to confirm this and to study the antipruritic ability of topical aspirin in inflamed skin. In 24 non-atopic volunteers, an inflammatory skin reaction was induced in forearm skin at 5 different sites by sodium lauryl sulphate contained in Finn Chambers. Aspirin 10%, aspirin 1%,...

The study was conducted to record the microbial inhabitants of the nirmal ear canal and isolate microbial infective agents in otitic ears in dogs. The microorganisms were isolated from 87.5% of normal ears, which included Staphylococcus spp. (37.5%) followed by S. pyogenes (25.0%), P. aeruginosa (12.5%) and E. coli (12.5%). The fungus Candida spp was isolated from 37.5% normal ears, which was a...

The results of numerous studies allow us to conclude that atopic dermatitis is one the most common inflammatory skin diseases in children. Most often, debuts at an early age and its prevalence child population can reach 1030%. Scientific forecasts, as well data from various researchers, indicate not only a significant increase number patients, but also worsening course dermatitis, which causes ...

This study aims to test the feasibility of a randomised clinical trial to evaluate how acupuncture affects atopic dermatitis (AD) symptoms and quality of life and to explore potential biomarkers that may be associated with AD. It is a sham-controlled trial in which 30 eligible patients will be randomly allocated in a 1 : 1 : 1 ratio to one of three groups: verum acupuncture (VA) group 1 (3 time...

Herbal remedies for skin care with antibacterial and antifungal activities are prepared from a variety of plant parts such as leaves, stem, root, bark and fruits. These medicines are administered topically and may be applied in the form of cream, lotion, soap, sap, solvent extract and ointment, and have been established to possess antimicrobial properties[1]. The delivery of drugs through the s...

Commonly known as saffron, Crocus sativus L and its active components have shown several useful pharmacological effects such as anticonvulsant, antidepressant, anti-inflammatory, antitumor, radical scavenger effects, learning and memory improving effects, etc. There has been an increasing body of data on saffron use in medical databases within the last 20 years. In the current review, the stren...

We investigated a spinal site for opioid modulation of itch-related scratching behavior in rats. Intradermal 5-HT (2%, 10 microl) elicited intermittent bouts of hindlimb scratching directed toward the injection site (nape of neck) beginning within minutes and lasting >1 hr. 5-HT-evoked scratching was significantly reduced by systemic administration of the opiate antagonist naltrexone but was no...

There have been considerable advances in our understanding of the pathophysiology of pruritus in recent years. The purpose of this review was to highlight itch entities in women, and in particular pruritic vulvar dermatoses that women experience among different age groups. Unique temporal shifts may contribute to the etiology of many of these conditions. These changes lead to cyclical changes i...