abstractferulago angulata boiss. known in iran as chavir, has some bioactive compounds having antioxidant activity. because of its antioxidant activities, it sounded chavir extract can be a good candidate for finding chemopreventive agents having inductive apoptosis properties on cancer cells. in this study, the cytotoxic effects and proapoptotic activities of chavir’s leaf and flower extracts ...

the oxidative stress causes many diseases in human, therefore antioxidants have a specialposition in the medicinal chemistry. tyrosol is an important antioxidant with a plenty ofbiological properties. there are many strategies such as clustering single drug units in orderto develop new drugs. the cluster effect can increase drug effects relative to single drug unit.calixtyrosol is the novel clu...

Lipases are efficient enzymes with promising applications in the nutraceutical and food industry, as they can offer high yields, pure products under achievable reaction conditions, an environmentally friendly option. This review addresses production of high-value-added compounds such fatty acid esters, potential to be used flavoring agents or antioxidant antimicrobial agents, well structured li...

background: medicinal plants (especially belong to lamiaceae family) are potential sources of new drugs to improve the treatment of diseases whose treatment is associated to anti-oxidative agents. in this paper, the ferric reducing ability of plasma (frap) activity of some lamiaceae and apiaceae species, has been evaluated. methods: aerial parts of the plants were dried, cut into small pieces a...

antioxidant activities protect the cell against oxidative agents that are constant metabolic by-products. the aim of this study was to investigate the relationship between harvesting time of thymus transcaspicus and its antioxidant activities. the plant samples were harvested 5 times in different growth phases from 17 april to 22 july 2008, and its antioxidant activity was studied using the fer...

Honey has been used since long time both in medical and domestic needs, but only recently the antioxidant property of it came to limelight. The fact that antioxidants have several preventative effects against different diseases, such as cancer, coronary diseases, inflammatory disorders, neurological degeneration, and aging, led to search for food rich in antioxidants. Chemoprevention uses vario...

SIGNIFICANCE Intrarenal oxidative stress plays a critical role in the initiation and progression of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of reactive oxygen species (ROS) in the context of concomitant, insufficient antioxidant pathways. Renal ROS production in diabetes is predominantly mediated by various NADPH oxidases (NOXs), but a defective anti...

In the last decade the simplistic, stepwise concept of initiation, promotion, and progression has matured to a better understanding of the genotypic changes that ultimately lead to cancer. The hypothesis has been proposed that it may be possible to intervene pharmacologically during this process and that carcinogenesis may be arrested or reversed by synthetic or naturally occurring agents. Evid...

Leukaemia is a malignant disease of the blood. Current treatments for leukaemia are associated with serious side-effects. Plant-derived polyphenols have been identified as potent anti-cancer agents and shown to work synergistically standard chemotherapy in cell lines. Polyphenols multiple mechanisms action reported decrease proliferation, arrest cycle induce apoptosis via activation caspase (3,...

Friedreich's ataxia is a debilitating progressive neurodegenerative disease associated with cardiomyopathy and other features. The underlying cause is a deficiency of the mitochondrial protein frataxin which causes mitochondrial iron deposition, increased oxidative stress and impaired adenosine triphosphate production. Over the last 15 years, multiple clinical trials have assessed the efficacy ...