The primary small vessel systemic vasculitides are disorders that target small blood vessels, inducing vessel wall inflammation and associated with development of antineutrophil cytoplasmic antibodies. Multiple organs are attacked including the lungs and kidneys. Increasing knowledge of pathogenesis suggests that the antibodies activate neutrophils inappropriately, leading to endothelial and va...

objective: the study aimed to determine the relationship between presence of antiphospholipid antibodies (apls) and clinical pregnancy rate in patients undergoing ivf/icsi procedures. materials and methods: this descriptive-analytic study performed on two hundred consecutive women referred for ivf/icsi in vali-e-asr reproductive health research center. serum levels of apls , anticardiolipin [ac...

antineutrophil cytoplasmic autoanibodies (anca) were detecte in patients with certain autoimmune vascular disease such as wegner’s granulomatosis, polyarthrits nodosa and systemic luuc erythematous. indirect immunofluorescence (iif) technique was employed to detec these autoantibodies.anca have been recently detected in some forms of inflammatory bowel disease (ibd), ulcerative colitis (u.c). c...

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a necrotizing vasculitis of small and medium-sized blood vessels characterized by diffuse inflammation vascular structures perivascular extravascular granulomatosis. In its systemic form, GPA predominantly affects the ear, nose throat, lung kidney involvement typically rapidly progressive glomerulonephritis e...

Clinical recognition of drug-induced vasculitic and lupus-like syndromes is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary haemorrhage). Withdrawal of the drug often leads to spontaneous recovery, meaning that immunosuppressive therapy can be avoided. The presence of myel...

TOPIC: Pulmonary Manifestations of Systemic Disease TYPE: Fellow Case Reports INTRODUCTION: Antineutrophil cytoplasmic antibodies – associated vasculitis (AAVs) are a rare group diseases that primarily affect small vessels. If left untreated, they can lead to significant morbidity and mortality. We present case diffuse alveolar hemorrhage (DAH) in patient with recently diagnosed end stage renal...