Punicalagin (PC) is an ellagitannin found in the fruit peel of Punica granatum. We have demonstrated antioxidant and antigenotoxic properties of Punica granatum and showed that PC and ellagic acid (EA) are its major constituents. In this study, we demonstrate the antimutagenic potential, inhibition of BP-induced DNA damage, and antiproliferative activity of PC and EA. Incubation of BP with rat ...

Cleistocalyx nervosum var. paniala, an edible fruit found in Northern Thailand, contains high amounts of phenolic compounds with in vitro antioxidant activity. The aqueous extract of the ripe fruit was evaluated for its safety and beneficial effects using genotoxicity and toxicity tests. The C. nervosum extract was not only non-mutagenic in Salmonella typhimurium strains TA98 and TA100 in the p...

Recently, there have been considerable efforts to search for naturally occurring substances that can inhibit, reverse, or retard the multi-stage carcinogenesis. A wide array of phenolic substances derived from edible and medicinal plants have been reported to possess anticarcinogenic and antimutagenic activities and in many cases, the chemopreventive activities of phytochemicals are associated ...

In the present investigation, antimutagenic effect of petroleum ether, chloroform, methanol and water extracts of green tea was evaluated in Salmonella typhimurium TA-98 and TA-100 strains. Well known mutagens like sodium azide and daunomycin were added at a concentration of 10µl and 6µl per plate respectively resulted in the induction of histidine revertant colonies. However addition of 10 µl ...

Purple sweet potato is a source of anthocyanins that function as antioxidants, antimutagenic, and anti-carcinogenic so it has the potential to be processed into various functional food products. The stability anthocyanin levels in product greatly influenced by temperature during processing, where use high temperatures will damage reduce levels. This research was conducted determine effect proce...