نتایج جستجو برای: antileishmanial properties
تعداد نتایج: 870269 فیلتر نتایج به سال:
Physalis angulata L., Solanaceae, is an annual herb commonly used in popular medicine in many tropical and subtropical countries. P. angulata extracts contain a variety of substances, but little is known about their pharmacological activities. In this work we investigated the in vitro antileishmanial activity of seco-steroids (physalins) purified from P. angulata. Addition of physalins B, F, an...
The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along with soluble derivatives (potassium salt) and acetate was obtained. All the compounds were assayed against metacyclic promastigotes of two different species of Leishmania associated to tegumentar leishmaniasis: L. amazonensis and L. braziliensis. All compounds presented significant activity, being isolapachol acet...
Initially, the use of liposomes was mainly confined to model membrane systems, however, recently their use as vehicles for transfer of genetic and other materials into cells in cultures or for drug delivery to desired cellular and subcellular sites in a living system has been the subject of discussion. Liposomes can vary widely in size, chemical composition, and surface characteristics; they ca...
In the absence of effective vector control measures and vaccines against leishmaniasis, effective chemotherapy remains the mainstay of treatment. As the armoury of antileishmanial drugs is limited, strategies should be made to target the emergence of drug resistance. The loss of efficacy of antimonials such as sodium stibogluconate in the Indian subcontinent which has been the mainstay of treat...
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