We have compared the efficacy of granisetron in combination with dexamethasone with each drug alone in the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. In a randomized, double-blind study, 120 patients (85 females) received granisetron 3 mg, dexamethasone 8 mg or granisetron 3 mg with dexamethasone 8 mg i.v. (n = 40 in each group), immediately before inductio...

zine successfully reduced the incidence of dysphoric reactions it might also antagonise the antiemetic effect of nabilone. The incidences of other side effects were similar in both treatment arms; sedation and dryness of the mouth occurred most commonly and generally were not too troublesome. Indeed, we suspect that with moderately emetogenic cytotoxic regimens5 the occurrence of these side eff...

Although the public debate about the legalization of marijuana has continued for as long as 25 years, few controlled studies have been conducted to assess its potential medical benefits. The present study examined the antiemetic effect of smoked marijuana cigarettes (8.4 and 16.9 mg Delta(9)-tetrahydrocannabinol [THC]) compared to a highly potent antiemetic drug, ondansetron (8 mg) in 13 health...

Nausea and vomiting are the toxicities of chemotherapy most feared by the cancer patient. However, increased understanding of the mechanisms of nausea and vomiting has led to greatly improved control of this toxicity. Greater flexibility of dose, schedule, and route of administration of effective antiemetic agents has played a significant role in making outpatient administration and management ...

A three-year observational study of patients undergoing tonsillectomy at the University Hospital of the West Indies was conducted to determine the incidence of postoperative vomiting. Data were collected to assess possible risk factors for vomiting as well as possible alleviating agents. Two hundred and fifty-two patients were included in the study and a thirteen per cent incidence of postopera...

BACKGROUND Antiemetic triplet therapy including dexamethasone (DEX) is widely used for patients receiving highly emetogenic chemotherapy (HEC). In Japan, the appropriate dose of DEX has not been established for this combination. MATERIALS AND METHODS To assess the efficacy and safety of increased-dose DEX, we retrospectively examined patients receiving HEC with antiemetic triplet therapy. R...

Nausea and vomiting are the common complication during and after spinal anesthesia antiemitic drugs reduce vomiting, but have some potential side effect. Acupressure is a nonagressive and without drug effect method that some the researcher suggest that this method can be used as a approach to reduce nausea and vomiting. Objective: This study is a clinical trial which is aimed to evaluate the ef...

Laparoscopic cholecystectomy is associated with significantly high rate of post operative nausea and vomiting (PONV). This study was designed to compare the effectiveness of Ondansetron with that of Granisetron for prevention of PONV after laparoscopic cholecystectomy. In a randomized, prospective study, 100 patients were selected and randomly divided into two groups of 50 each. Group one recei...

BACKGROUND Chemotherapy-induced nausea and vomiting (CINV) is one of the most debilitating toxicities associated with cancer treatment. Although effective antiemetic agents are available, their use in practice often is suboptimal. METHODS The author reviews the pathophysiology of CINV as well as the drug classes and cost considerations that should be incorporated into treatment planning. RE...