This research aimed to determine the active fraction and profile of compounds in Manonjaya sSnakefruit skin extract that can be used as antidiabetic activity using zebra fish. was extracted by maceration 70% ethanol then fractionated n-hexane, ethyl acetate methanol. The showed highest yield total phenolic content well strongest α-glucosidase inhibition with an percentage 64.43%. provided most ...

Diabetes and cancer are a major global public health problem. Plant-derived agents with undesirable side-effects were required. This study aimed to evaluate antidiabetic and anticancer activities of the ethanolic leaf extract of Mangifera indica cv. Okrong and its active phytochemical compound, mangiferin. Antidiabetic activities against yeast α-glucosidase and rat intestinal α-glucosidase were...

Introduction: Leaves of mempelas paya (Tetracera indica) (family: Dilleniaceae) is traditionally used in diabetes management in Malaysia. However, no attempt has ever been made to discover an active principle responsible for its blood glucose lowering effect. Hence, this research deals with the isolation, in vivo antidiabetic and toxicological evaluation of an active principle. Methods: Chemica...

Diabetes mellitus is one of the major disease currently affecting an estimated 143 million people worldwide and the number is growing rapidly. Now a day, as there is a renewed interest in the traditionally used herbal drugs, the present study was aimed to screen the identified constituents of Helicteres isora for determining the potent constituent with antidiabetic activity using insilico appro...

The complex metabolic syndrome, diabetes mellitus, is a major human health concern in the world and is estimated to affect 300 million people by the year 2025. Several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycemia in diabetes mellitus. These drugs have side effects and thus searching for a new class of compounds is essential to overcome this problems...

The complex metabolic syndrome, diabetes mellitus, is a major human health concern in the world and is estimated to affect 300 million people by the year 2025. Several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycemia in diabetes mellitus. These drugs have side effects and thus searching for a new class of compounds is essential to overcome this problems...

UNLABELLED Medicinal plants and plant derived molecules are widely used in traditional cultures all over the world and they are becoming large popular among biomedical researchers and pharmaceutical companies as a natural alternative to synthetic medicine. Information related to medicinal plants and herbal drugs accumulated over the ages are scattered and unstructured which make it prudent to d...

A novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the 2,4-thiazolidinedione moiety. These compounds were evaluated for glucose and lipid lowering effects in genetically obese and diabetic KKA(y) mice. Several of the compounds showed strong antidiabetic activity, including functional potency at peroxisom...

The aim of the present study was to investigate the antidiabetic and renal protective effect of Momordica dioica extract (MDMtE) in streptozotocin-diabetic rats. MDMtE treatment markedly reduced serum glucose, increased serum insulin and urea levels. Study results indicated that the antioxidant enzyme activity of kidney was increased, while thiobarbituric acid reactive substances (TBARS) were r...

The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570 +/- 29 to 401 +/- 59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significan...