BACKGROUND The neuropharmacological actions of antidepressants are well characterised but our understanding of how these changes translate into improved mood are still emerging. AIMS To investigate whether actions of antidepressant drugs on emotional processing are a mediating factor in the effects of these drugs in depression. METHOD We examined key published findings that explored the eff...

OBJECTIVE To assess trends in the use of antidepressants among young suicides after the warning that these drugs might increase the risk of suicide. METHOD Individual data of all 845 suicides in the 10- to 19-year age group in Sweden in the time period 1992-2003 (baseline), and in 2004-2010 (after the warning). Outcome data are prescriptions of antidepressants prior to death and detections of...

background major depressive disorder (mdd) is the most common disorder in our community. hypericum perforatumm, is a herb with a long application history in treating depression. a controlled study to evaluate the effects of this herbal medicine in iran did not exist. objectives this study aimed to assess the effect of hypericum perforatom (perforan), in combination with tricyclic antidepressant...

We focused on the application of antidepressants in schizophrenia treatment in this review. Augmentation of antidepressants with antipsychotics is a common clinical practice to treat resistant symptoms in schizophrenia, including depressive symptoms, negative symptoms, comorbid obsessive-compulsive symptoms, and other psychotic manifestations. However, recent systematic review of the clinical e...

Antidepressants are first-line treatment for patients with major depressive disorder (MDD). The mechanism of action of antidepressants is still not completely understood. While most antidepressants directly inhibit the reuptake of at least one monoamine neurotransmitter in the brain (serotonin, dopamine or noradrenalin), or block their degradation, mirtazapine, tianeptine and agomelatine, which...