Several different interventions improve depressed mood, including medication and environmental factors such as regular physical exercise. The molecular pathways underlying these effects are still not fully understood. In this study, we sought to identify shared mechanisms underlying antidepressant interventions. We studied three groups of mice: mice treated with a widely used antidepressant dru...

Introduction: Depression is a widely prevalent form of mental illnesses worldwide. It commonly associated with sad mood, loss interest or pleasure, feelings guilt low self-worth, disturbed sleep appetite, and energy. Mimosa pudica has many medicinal properties, are used in traditional medicine the treatment various medical conditions. This study was conducted to better understand antidepressant...

OBJECTIVES To examine, among young women, the association of individual hormonal contraceptives, within two broad groupings, with antidepressant therapy. METHODS In a nationwide register-based study, we examined the prescription rates of antidepressant drugs in relation to individual combined hormonal and progestin-only contraceptives among Swedish women aged 16-31 years (N = 917,993). Drug d...

Objectives: To determine if the number of clinic visits affects placebo or drug response in antidepressant trials of late life major depression. Method: A previous systematic review of placebo-controlled antidepressant trials in late life depression was updated. Selected trials randomized patients to antidepressant or placebo and included community dwelling patients aged 60 and older, with Majo...

30 Wake Forest School of Medicine This study examined the effects of venlafaxine and quetiapine in a nonhuman primate model predictive of antidepressant drug effects. Twelve experimentally naïve male cynomolgus monkeys were trained to respond under a food-reinforcement schedule shown to have predictive validity in models of antidepressant activity (a differentialreinforcement-of-low rates; DRL ...

OBJECTIVES The relation between the use of different hormonal contraceptives and antidepressant therapy was investigated. METHODS In a nationwide cross-sectional study among all women in Sweden aged 16-31, drug expenditure data on hormonal contraceptives and antidepressants were obtained from the Swedish Prescribed Drug Register. Odds ratios (ORs) for antidepressant use were calculated by log...

CONTEXT Psychotropic medications are widely prescribed, but how new classes of psychotropic medications have affected prescribing patterns has not been well documented. OBJECTIVE To examine changes between 1985 and 1994 (data from 1993 and 1994 were combined) in the prescribing patterns of psychotropic medications by office-based primary care physicians, psychiatrists, and other medical speci...

There have been longstanding concerns about the propensity of antidepressants to precipitate suicidality in vulnerable individuals. To investigate this further, first we have analyzed all clinical trials, and in particular trials submitted to regulators for evidence on the relative risk of antidepressants versus placebo for this hazard. Second, we have compiled current epidemiological evidence ...

In this research at the first 2-amino-3-(3,4-dihydroxyphenyl) propanoic aciddrug  drug and its fullerene derivative were optimized. NBO calculations and NMR for the complexes were carried out at the B3LYP/6-31G*quantum chemistry level. Different parameters such as energy levels, the amount of Chemical Shift in different atoms, the amount of HOMO/LUMO, chemical potential (µ ), chemical hardness ...

BACKGROUND Systematic reviews of randomised placebo controlled trials of antidepressant medication show small and decreasing differences between pharmacological and placebo arms. In part this finding may relate to methodological problems with conventional trial designs, including their assumption of additivity between drug and placebo trial arms. Balanced placebo designs, which include elements...