نتایج جستجو برای: antibiotic treatment
تعداد نتایج: 1453454 فیلتر نتایج به سال:
The inoculum effect (IE) refers to the decreasing efficacy of an antibiotic with increasing bacterial density. It represents a unique strategy of antibiotic tolerance and it can complicate design of effective antibiotic treatment of bacterial infections. To gain insight into this phenomenon, we have analyzed responses of a lab strain of Escherichia coli to antibiotics that target the ribosome. ...
Daptomycin (DAP) is a calcium (Ca2+)-dependent FDA-approved antibiotic drug for the treatment of Gram-positive infections. It possesses complex pharmacophore hampering derivatization and/or synthesis analogues. To mimic Ca2+-binding effect, we used chemoenzymatic approach to modify tryptophan (Trp) residue DAP and synthesize kinetically characterized structurally elucidated regiospecific Trp-mo...
Antibiotic resistance evolves rapidly in response to drug selection, but it can also persist at appreciable levels even after the removal of the antibiotic. This suggests that many resistant strains can both be resistant and have high fitness in the absence of antibiotics. To explore the conditions under which high-fitness, resistant strains evolve and the genetic changes responsible, we used a...
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