Sjukhusrelaterade infektioner är en vanlig orsak till dödlighet och lidande runt om i världen. Ett allt större intresse har visats detta ämnesområde och WHO har påpekat vikten av att jobba med dessa frågor. Problemet är störst på sjukhusens intensivvårdsavdelningar där de sjukaste patienterna vårdas. Förekomsten av bakterier som är resistenta mot ett eller flera antibiotika är också störst på d...

Aims: The general aims of the present studies were to assess the levels of antibiotic resistance, in relation to antibiotic consumption at the Karolinska University Hospital, Solna (KS) and at 11 other Swedish hospitals, furthermore to assess the role of the membrane protein OprD and penicillin-binding proteins in Pseudomonas aeruginosa resistance to imipenem. Methods: Resistance figures were r...

The optimisation of antibiotic use to maximise patient care and safety through antibiotic stewardship forms one of the cornerstones of the global response to antibiotic resistance. Stewardship efforts in low- and middle-income countries are challenged by lack of healthcare professionals trained in infection. Therefore, in resource-poor settings, the traditional model of infection specialist-led...

Methods In a retrospective case control study between June 2009 and June 2010 at Santa Casa de Misericórdia Hospital, city of Ponta Grossa, south Brazil, 61 Klebsiella spp. (29 ESBL and 32 controls non-ESBL-producing isolates) were enrolled. ESBL were screened by disk diffusion method and double disk approximation method, according to CLSI. Prior use of antibiotic was analyzed in electronic me...

To optimize use of antimicrobial agents in human and animal, as recommended by the WHO Global Action Plan [3], countries need to develop a sustainable system which monitors their consumption and disseminate the information for policy decision. For example, France had a high human antibiotic use in the EU, and implemented a national campaign which resulted in a significant reduction in consumpti...

BACKGROUND The association between antibiotic use in the community and antimicrobial resistance is known. Attention has recently focused on the type of agents being prescribed. OBJECTIVES To implement, evaluate and compare the efficacy of two community intervention programs--continuous versus seasonal medical education--oriented to primary care physicians with emphasis on the appropriate use ...