Myasthenia Gravis (MG) is a neuromuscular junction disorder caused by pathogenic autoantibodies to some parts of the post-synaptic muscle endplates. About 85% of generalized MG patients have autoantibodies against post-synaptic acetyl-choline receptors (AChR). From the 10-15% of the remaining patients, 45-50% are positive for Muscle Specific Tyrosine Kinase-Antibody (MuSK-Ab). It is believed th...

Background: Ligustrazine, active ingredients extracted from the natural herb Ligusticum Chuanxiong Hort, has promising anti-tumor properties on tumor cell lines. However, potential activity of ligustrazine colorectal cancer (CRC) cells and molecular mechanisms have not been elucidated. In this study, we explored critical functions SW480 CT26 at cellular levels.

Abstract Head and neck squamous cell carcinoma (HNSCC) is amongst the rapidly growing form of cancer associated with high mutation burden Human Papilloma virus (HPV) infection presenting approximately 800,000 new cases 400,000 deaths annually. HPV-positive HNSCC has been strongly better prognosis than HPV-negative due to immune activation in tumor microenvironment including cytotoxic CD8+ T cel...

Abstract Background Immune checkpoint blockade (ICB)-based cancer immunotherapy presents promising efficacy in treatment. However, only a small portion of patients show responsiveness to the treatment, which is partially caused by limited tumor infiltration T cells. Chemokines CXCL9, CXCL10 and CXCL11 bind their receptor CXCR3 regulate cell invasion. Methods We delivered plasmids encoding cells...

Background KD033 is a clinical-stage bispecific fusion molecule consisting of high-affinity anti-human-PD-L1 antibody and human IL-15. Previous studies with in mice expressing functional PD-1 PD-L1 showed that was efficacious reducing the growth both positive negative tumors. 1 In microenvironment tumors, would still be expressed by some immune cells such as macrophages. The goal current study ...

background: chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. in vitro studies have been shown that arteether (are) induces apoptosis in tumor cells, but not in normal cells. objective: to investigate the cytotoxic and immunomodulatory properties of arteether in-vivo and in-vitro. methods: in this study, we ...

Tumor-derived exosomes (TEXs) are a class of extracellular vesicles which play an important role in the tumor microenvironment. These have multiple biological functions including promotion cancer progression and reduction anti-tumor immunity. Recently, interaction between TEXs immune cells great interest cell-based immunotherapy. Here, we review effects on survival T cell subsets, as well their...

BACKGROUND In osteosarcoma, the presence of tumor-infiltrating macrophages positively correlates with patient survival in contrast to the negative effect of tumor-associated macrophages in patients with other tumors. Liposome-encapsulated muramyl tripeptide (L-MTP-PE) has been introduced in the treatment of osteosarcoma patients, which may enhance the potential anti-tumor activity of macrophage...

Thioridazine, a member of the phenothiazine family, is a powerful anti-anxiety and anti-psychotic drug. It can also suppress the growth of several types of tumor in vitro. In the current study, we evaluated the direct anti-tumor and anti-angiogenic effects of thioridazine in vivo. The injection of thioridazine into human ovarian tumor xenografts in nude mice significantly inhibited tumor growth...