a twelve-year-old girl with disseminated tuberculosis was complicated by psychogenic vomiting and multiple drugs’ adverse effects. she was admitted to our hospital, complaining of fever, cough and abdominal pain. diagnosis of tb was obtained by abdominal ct-scan and open liver biopsy. during the anti-tb treatment, hepatitis, hemolytic anemia and pancreatitis occurred due to some drugs' side eff...

Abstract Background Previous studies have shown significant differences and lack clarity on whether resistance to either isoniazid or rifampicin can predict multidrug tuberculosis (MDR-TB). Some consider be a surrogate for MDR-TB. We, therefore, conducted this study determine Results A total of 315 Mycobacteria isolates were tested against isoniazid, rifampicin, ethambutol streptomycin using th...

the aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in iranian pulmonary tuberculosis patients. acetylating phenotypes was studied in 50 iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-isoniazid to isoniazid. the association between hepatotoxicity and the n-acetyltransferas...

The use of drugs in fixed-dose combination (FDC) is now recommended by the World Health Organization (WHO) due to the emergence of multidrug-resistant strains of Mycobacterium tuberculosis. FDC uses different drugs against tuberculosis (TB) in a single tablet for phase-intensive therapeutic intervention. This therapy aims to optimize treatment, to prevent inappropriate use of drugs, and to prev...

SUMMARY AND KEY RECOMMENDATIONS: The aim of these guidelines is to describe a practical but evidence-based approach to the diagnosis and treatment of central nervous system tuberculosis in children and adults. We have presented guidance on tuberculous meningitis (TBM), intra-cerebral tuberculoma without meningitis, and tuberculosis affecting the spinal cord. Our key recommendations are as follo...

Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...

Discovery of novel drug against tuberculosis is inevitable since resistant bacterial strains are evolved existing drugs and rapidly active single in short period necessary for effective treatment. When compared to synthetic drugs, natural particularly phytochemicals induce less side effects long term stability. In Indian traditional medicine, several plant species have been used treating each c...

Currently, no information is available on the effect of resistance/susceptibility to first-line drugs different from isoniazid and rifampicin in determining the outcome of extensively drug-resistant tuberculosis (XDR-TB) patients, and whether being XDR-TB is a more accurate indicator of poor clinical outcome than being resistant to all first-line anti-tuberculosis (TB) drugs. To investigate thi...

OBJECTIVE Human tuberculosis (TB) has re-emerged at an alarming rate as one of the deadliest contagious diseases; not only in the developing world, but also in the developed countries. Its re-emergence indicates failure to control its transmission. What causes part of the alarm is the growing number of isolates displaying resistance to the first line drugs used in its control. The very high vol...