background: celiac disease is a common autoimmune disorder that is diagnosed based on clinical case identification, serological screening, and duodenal histology. however, the existence of mild clinical forms, such as seronegative cases with patchy atrophy and potential celiac disease, can make it difficult to determine a definitive diagnosis. the seronegative patients with celiac disease can i...

Since transglutaminases create covalent gamma-glutamyl-epsilon-lysine cross-links between extracellular matrix proteins they are prime candidates for stabilizing tissue during wound healing. Therefore, we studied the temporo-spatial expression of transglutaminase activity in skin regenerating from cultured epithelial autografts in severely burned children by the specific incorporation of monoda...

Transglutaminase 2 (TGase 2), or tissue transglutaminase, catalyzes either epsilon-(gamma-glutamyl)lysine or N(1), N(8)-(gamma-glutamyl)spermidine isopeptide bonds. TGase 2 expression has been associated with apoptosis, and it has been proposed that its activation should lead to the irreversible assembly of a cross-linked protein scaffold in dead cells. Thus, TGase 2-catalyzed protein polymeriz...

OBJECTIVE: To find out the clinical profile and association of Celiac Disease (CD) in children with established type-1 Diabetes Mellitus (T1DM) presenting a tertiary care hospital Karachi, Pakistan. METHODS: This cross-sectional study was conducted from January-2019 to July-2019 at National Institute Child Health, A total 126 T1DM patients age 1-18 years were subjected detailed history examinat...

background: celiac disease (cd) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (lft). as there is no precise data from our country in this regard, we investigated the prevalence of cd in patients presenting with abnormal lft. methods: from 2003 to 2008, we measured iga anti-tissue transglutaminase (t-tg) antibody (with elisa technique) with...

introduction cow’s milk allergy is the most common food allergy in children. symptoms usually involve the skin and the gastrointestinal and respiratory tracts. gastrointestinal tract manifestations of cow’s milk allergy are nonspecific, and are the only type that can be diagnosed in all age groups. here, we report a rare case of cow's milk allergy in an infant with hypoalbuminemia and malnutrit...