Microinjection of kappa opioid receptor (KOR) agonists into the rostral ventromedial medulla (RVM) attenuates mu-opioid receptor mediated antinociception and stress-induced analgesia, yet is also reported to have an analgesic effect. To determine how KOR agonists produce both antinociceptive and anti-analgesic actions within the RVM, the KOR agonist U69593 was microinjected directly into the RV...

Fruits of Olea europaea L. have been used for centuries in folk medicine to treat many inflammatory diseases. In order to evaluate the anti-nociceptive activities of the methanolic and aqueous extracts of defatted fruits of O. europaea, formalin test was used and for evaluation of anti-inflammatory effects of the extract, the volume of paw edema was measured. The results revealed that both extr...

In many field observation, ecological equipment, phenology and ethnopharmacological data of Achillea millefolium L. and A. micrantha Wild. were studied. The inflorescences of plants were collected in different locations of Golestan province: Chaharbagh (2000 m) and Dozan (2200 m) respectively. Essential oils were obtained by steam distillation (Clevenger) and analyzed by gas chromatography-mass...

This study was designed to investigate the anti-inflammatory and anti-nociceptive activity of the methanol extract from the aerial part of Phlomis younghusbandii (MEAP) and to explore the possible related mechanisms. Anti-inflammatory effects of MEAP were evaluated by using the ear edema test induced by dimethylbenzene and vascular permeability test induced by acetic acid. Anti-nociceptive acti...

Apple Cider Vinegar (ACV) is a natural compound that is used mainly in numerous food preparations. During the last few decades, ACV has been used for various therapeutic purposes in different countries. One of its main applications by people in Iran and other countries has been as an oral traditional remedy to control chronic pain in arthritis. In this study, ACV’s effects on acute and chronic ...

Hibiscus rosasinensis L. (Malvaceae) is used in folk medicine for the treatment of pain and various inflammatory conditions such as the inflammation of oral mucosa, blenorrhoea, and asthmatic bronchitis. In the present study the methanolic extract of Hibiscus rosasinensis leaves ( 250 and 500 mg/kg body weight orally) was studied for anti-nociceptive and anti-inflammatory activities in various ...

Introduction: The aim of this review article was to analyze in details the mechanism drugs’ effects treatment and prevention a migraine attack, as well discuss hypotheses pathogenesis.
 Migraine attack agents: main agents for have an anti-nociceptive activity.
 Agents preventive treatment: β-blocker propranolol also has anti-serotonin analgesic activities, most drugs used prophylactic...

Hunger and pain are two competing signals that individuals must resolve to ensure survival. However, the neural processes that prioritize conflicting survival needs are poorly understood. We discovered that hunger attenuates behavioral responses and affective properties of inflammatory pain without altering acute nociceptive responses. This effect is centrally controlled, as activity in hunger-...

Objective. To estimate an anti-nociceptive and regenerative potential of adipose-derived mesenchymal stem cells in experimental post-traumatic neuropathy rats. Methods. Neuropathic pain was induced by axotomy technique rat left hind paw (Wistar rats (n=113)). The respective group subjects received ADMSCs dose 1×10<sup>6</sup> cells/kg 2×10<sup>6</sup> into the site sciat...