Lipids are important constituents of the human epidermis. Either free and organized into broad lipid bilayers in the intercorneocytes spaces, or covalently bound to the corneocyte envelope, they play a crucial role in permeability barrier function and are major contributors to cutaneous anti-microbial defense. Free sphingoid bases are a recent addition to this family of active lipids, which eme...

The nematode parasites Wuchereria bancrofti, Brugia malayi, and B. timori cause a human disease known as lymphatic filariasis, which afflicts approximately 120 million people worldwide. These organisms are known to contain endosymbiotic bacteria (Wolbachia) that are related to rickettsiae. It has been previously reported that tetracycline blocks the L3 to L4 molt of the filarial parasite B. mal...

Dhava (Anogeissus latifolia), Combretaceae family, commonly known as Bakali or Axlewood, is a prominent herb in Ayurveda which used food medicine and other since long ago. This article reviews the various references of Ayurvedic texts regarding its therapeutic uses different formulations. The review also encompasses pharmacological activities folklore this plant. It medicinally management sever...

Enterococcus faecalis is a pathogenic Gram-positive bacterium, which mainly infects humans through urinary tract infections. SrtA is an essential enzyme for survival of E. faecalis, and inhibition of this particular enzyme will reduce the virulence of biofilm formation. It is proved to be associated with the microbial surface protein embedded signal transduction mechanism and promising as a sui...

i ntroduction: calcium hydroxide (ch) is one of the most common intracanal medications. corticosteroids (cs) are used in endodontics because of their anti-inflammatory activity. this study aimed to evaluate the antimicrobial effect of ch+betamethasone and ch+saline against enterococcus faecalis ( e. faecalis ) using agar diffusion test and measuring the microbial zone of inhibition (zoi). metho...

In acne different pathogenetic factors contribute to the inflammation process, defect in keratinisation, increased sebaceous gland activity and increased colonisation of Propionibacterium acnes. The results of in vitro and in vivo studies confirm the previous reports on strong anti-microbial effectiveness of phytosphingosine in vitro and in vivo. In addition, phytosphingosine shows excellent cl...

Alafia zambesiaca is a medicinal plant used widely in Ghana for the treatment of gastric/peptic ulcers. The objective this study was to comparatively assess effect methanolic and diethylether extracts phytochemicals on three bioactivities indicative ulcers etiology. Using standard laboratory assays involving broth dilution, carrageenan-induced foot swelling 7-day old chicks DPPH radical scaveng...

Defensins are antimicrobial peptides expressed by plants and animals. In mammals there are three subfamilies of defensins, distinguished by structural features: alpha, beta and theta. Alpha and beta-defensins are linear peptides with broad anti-microbial activity that are expressed by many mammals including humans. In contrast, theta-defensins are cyclic anti-microbial peptides made by several ...

Skin exudates of rainbow trout contain a potent 13.6 kDa anti-microbial protein which, from partial internal amino acid sequencing, peptide mass fingerprinting, matrix-associated laser desorption/ionization MS and amino acid analysis, seems to be histone H2A, acetylated at the N-terminus. The protein, purified to homogeneity by ion-exchange and reversed-phase chromatography, exhibits powerful a...