Frequent incidents of antibiotic-resistant biofilm forming pathogens in community-associated and hospital-acquired infections have become a global concern owing to failure of conventional therapies. Nano-antibiotics (NABs) are de novo tools to overcome the multi-drug resistant mechanisms employed by the superbugs. Inhibition of biofilm formation is one of those strategies to curb multi drug res...

Outer Membrane Protein (OMP) enriched extracts of Pasteurella multocida A:1 (“A”) and local isolate (“L”) obtained from Nutrient rich free cell (FC), Nutrient deficient free cell (DC) and Biofilm cell (BC) growth were analyzed by SDS-PAGE. In general, the OMP profile in all the three growth conditions of “A” was different from that of “L” suggesting that both could be of different serotype. The...

A new strain, namely Lysinibacillus sp. BV152.1 was isolated from the rhizosphere of ground ivy (Glechoma hederacea L.) producing metabolites with potent ability to inhibit biofilm formation of an important human pathogens Pseudomonas aeruginosa PAO1, Staphylococcus aureus, and Serratia marcescens. Structural characterization revealed di-rhamnolipids mixture containing rhamnose (Rha)-Rha-C10-C1...

Quorum sensing (QS) is an intercellular signaling and gene regulatory mechanism, which is implicated in bacterial pathogenicity and food spoilage. Therefore, blocking bacterial QS system may prevent QScontrolled phenotypes responsible for food spoilage. In the present study, we aimed to investigate the anti-biofilm and quorum sensing inhibitory potentials of Rosa rugosa tea polyphenol (RTP) ext...

Green nanotechnology is the evolution of cost-effective and environmentally friendly processes for production metal-based nanoparticles due to medicinal importance economic value. The aim present study was biosynthesize characterize silver (AgNPs) using seed extract Ajwa dates (Aw). anti-bacteriostatic activity biosynthesized Aw–AgNPs against Gram-positive Gram-negative bacterial strains evalua...

background the ability of candida albicans to form biofilms and adhere to host tissues and biomaterial surfaces is an important factor in its pathogenesis. one of the main characteristics of biofilms is their resistance to broad-spectrum anti-microbial drugs. objectives in the present study the formation of biofilm by c. albicans from different sources was evaluated. in addition, the minimum bi...

Due to the intrinsic resistance of Burkholderia cepacia complex (Bcc) to many antibiotics and the production of a broad range of virulence factors, lung infections by these bacteria, primarily occurring in cystic fibrosis (CF) patients, are very difficult to treat. In addition, the ability of Bcc organisms to form biofilms contributes to their persistence in the CF lung. As Bcc infections are a...

Catheter associated urinary tract infection (CAUTI) is the most common nosocomial infection, accounting for more than 1 million patients annually in United States acutecare hospitals and extended-care facilities. Infected urinary catheters are covered by a thick biofilm that contain the infecting organisms. These organisms are embedded in a matrix of host proteins and microbial slime. This biof...

Biofilm cells typically exhibit increased resistance to antimicrobial agents and the host immune system. In vitro antibiofilm activity has been studied widely in the present’s days. It has become necessary to apply various microscopic techniques in order to evaluate in situ anti-biofilm activity and ultrastructural changes. A wide variety of methods can be applied for visualization and quantifi...

Phage therapy has been proven to be more effective, in some cases, than conventional antibiotics, especially regarding multidrug-resistant biofilm infections. The objective here was to isolate an anti-Enterococcus faecalis bacteriophage and to evaluate its efficacy against planktonic and biofilm cultures. E. faecalis is an important pathogen found in many infections, including endocarditis and ...