Angiogenesis is required for the invasion, metastasis and chemoresistance of tumor cells. In addition to vascular endothelial cell growth factor (VEGF), angiopoietin-2 (Ang2) is considered to be a promising target for anti-angiogenic therapy. The T7 peptide, an active fragment of full-length tumstatin [the noncollagenous 1 domain of the type IV collagen α3 chain, α3(IV)NC1], has equivalent anti...

BACKGROUND Resveratrol increases nitric oxide (NO) production via increased expression and activation of endothelial-form-NO-synthase (eNOS) in endothelial cells. However, the role of downstream cGMP/protein kinase G (PKG) signaling, a pathway activated by NO/eNOS, in pro- and anti-angiogenic effects of resveratrol is still unclear. MATERIALS AND METHODS Endogenous NO/cGMP/PKG pathway and dow...

actinomycetes were isolated from marine sediment samples collected from the east coast of chennai, tamil nadu, india. well diffusion and agar plug methods were used for the evaluation of antibiotic production by these isolates against drug resistant methicillin- resistant staphylococcus aureus (mrsa) and vancomycin resistant enterococci (vre). the potential isolate vitbrk2 was mass cultured for...

Human mast cells (MCs) are divided in two types depending on the expression of tryptase and chymase in their granules. Literature data indicate that both tryptase and chymase are angiogenic, but there is currently no evidence of their direct angiogenic activity in vivo. In this study, we have investigated the capacity of tryptase and chymase to promote vasoproliferation in chick embryo chorioal...

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BACKGROUND Gliomatosis cerebri is a rare primary cerebral tumour entity characterized by diffuse infiltrative growth patterns representing a WHO grade III malignancy. The prognosis is dismal and therapeutical options are still controversial. In contrast to other high-grade gliomas, angiogenesis is thought to be absent in gliomatosis cerebri. PATIENTS AND METHODS Despite this assumption, histo...

vascular endothelial growth factor (vegf-a) is one of the most important regulatory factors in pathological and physiological angiogenesis. alternative splicing is a complicated molecular process in vegf-a gene expression which adds complexity to vegf-a biology. among all vegf-a exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic vegf-xxx to ant...