Background: The rapid increase of HIV-1 strains resistant to current antiretroviral drugs is a challenge for successful AIDS therapy. This necessitates the development of novel drugs, and to this end, availability of screening systems for in vitro drug discovery is a priority. Herein, we report the modification of a previously developed system for increased sensitivity, ease of use, and cost-ef...

HIV-1 Reverse Transcriptase (HIV-1 RT) has been the target of numerous approved anti-AIDS drugs that are key components of Highly Active Anti-Retroviral Therapies (HAART). It remains the target of extensive structural studies that continue unabated for almost twenty years. The crystal structures of wild-type or drug-resistant mutant HIV RTs in the unliganded form or in complex with substrates a...

Human immunodeficiency virus (HIV)-infected patients are at increased risk of developing cancer, particularly in the later stages of acquired immune deficiency syndrome (AIDS). Despite the advent of highly active anti-retroviral therapy (HAART), malignancy in this population is a leading cause of morbidity and mortality. Kaposi's sarcoma (KS) and AIDS-related non-Hodgkin's lymphoma (ARL) are th...

Background: Malaria and HIV/AIDS are rampant in subSaharan Africa with prevalence of one reinforcing the other control impactful on other. parasitaemia (MP) is increased HIV-infected individuals while certain drugs used latter cause decline MP but it uncertain how they affect malaria antigenaemia (MA). How bio-social disease characteristics MA this cohort unknown.
 Objectives: To determine...

BACKGROUND Cryptosporidium parvum causes an opportunistic infection in AIDS patients, and no effective treatments are yet available. This parasite possesses a single fatty acyl-CoA binding protein (CpACBP1) that is localized to the unique parasitophorous vacuole membrane (PVM). The major goal of this study was to identify inhibitors from known drugs against CpACBP1 as potential new anti-Cryptos...

© 2003 Canadian Medical Association or its licensors The HIV epidemic has had a dramatic impact on rates of tuberculosis (TB) and on TB control in populations where both infections are prevalent. HIV infection, in particular advanced HIV infection (AIDS), is more potent than any other risk factor for the progression to disease of recent or remotely acquired TB infection. It destroys or renders ...

Genetic disruption of insulin and insulin-like signaling pathways may extend lifespan. Hyperinsulinemia and insulin resistance may accelerate aging. The hypothesis was tested that a once-a-week life-long inhibition of insulin secretion by the administration of anti-lipolytic drugs might have anti-aging effects. Groups of 3-month-old male Sprague-Dawley rats were (a) given standard laboratory fo...

Unaffordable prices still bar the end-users in China from accessing ARV drugs. Patent protection of ARV drugs has dramatically limited the availability of these lifesaving drugs to AIDS patients in China.The way Chinese government can go to breakthrough the ARV drug patents are suggested as:Make more generic drugs available through compulsory licensing, impartment from other countries or buildi...