Objective(s):Estrogen (E2) has neuroprotective effects on blood-brain-barrier (BBB) after traumatic brain injury (TBI). In order to investigate the roles of estrogen receptors (ERs) in these effects, ER-α antagonist (MPP) and, ER-β antagonist (PHTPP), or non-selective estrogen receptors antagonist (ICI 182780) were administered. Materials and Methods: Ovariectomized rats were divided into 10 gr...

Background To compare a flexible, multi-dose GnRH antagonist protocol with a long GnRH .agonist protocol in poor respo MaterialsAndMethods A randomized clinical trial of 70 poor responder patients (35 patients in GnRH antagonist protocol and 35 patients in long GnRH agonist protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotr...

Giriş/Amaç:IVF-ET uygulanan 1000 siklusun GnRH antagonist ve agonist protokollerinin etkinliğinin karşılaştırılması amaçlanmıştır. Gereç Yöntemler:1000 siklus çalışmaya dahil edilmiştir,bu siklusların 283?üne protokol,717?sine protokol uygulanmıştır. Her iki grubu demografik özellikleri, tedavi karakteristikleri, gebelik oranları açısından karşılaştırılmıştır. Bulgular:Agonist grubunda ?coastin...

results: the most important diseases to consider in the differential diagnosis of fphl include chronic telogen effluvium (cte), permanent alopecia after chemotherapy (pac), alopecia areata incognito (aai) and frontal fibrosing alopecia (ffa). this review describes criteria for distinguishing these conditions from fphl. conclusions: the only approved treatment for fphl, which is 2% topical minox...

background: determination of oocyte fertilization and embryo quality are one of the most important purposes in art cycles. follicular fluid provides an important microenvironment for development of oocytes and some biochemical characteristics of the follicular fluid, such as pregnancy-associated plasma protein-a (papp-a), may play an important role in prediction of success rate of art. objectiv...

A 9-year-old boy affected by colchicine-resistant idiopathic pericarditis was successfully treated with an IL-1 receptor antagonist (anakinra).

In this paper we present a simple but useful profiling tool for OpenMP applications similar in spirit to the MPI profiler mpiP [15]. We describe the implementation of our tool and demonstrate its functionality on a number of test applications.

Small-angle X-ray scattering and nuclear magnetic resonance were used to investigate the structural change of calcium-bound calmodulin (Ca2+/CaM) in solution upon binding to its antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7). The radius of gyration was 17.4+/-0.3 A for Ca2+/CaM-W-7 with a molar ratio of 1:5 and 20.3+/-0.7 A for Ca2+/CaM. Comparison of the radius of gyratio...

The mechanisms of the action of bioactive compounds discovered via 'black box' assays using phenotypic indicators generally remain unknown, with the major challenges being the identification of target proteins. In this study, we aimed to develop an efficient methodology to unveil target proteins that are rarely characterised. Proof-of-concept experiments were performed using N-(6-aminohexyl)-5-...