Bacterial lipopolysaccharide (LPS), also known as endotoxin, induces profound anorexia. However, the LPS-provoked pro-inflammatory signaling cascades and the neural mechanisms underlying the development of anorexia are not clear. Mammalian target of rapamycin (mTOR) is a key regulator of metabolism, cell growth, and protein synthesis. This study aimed to determine whether the mTOR pathway is in...

It is now common to view anorexia nervosa as a multi-determined syndrome in which physical, psychological, family and sociocultural factors interact to produce the illness. Such a compromise position is difficult to refute. However, the components of this complex model neither explain nor account for the epidemiological and clinical features of the condition. A popular cultural thesis is that t...

BACKGROUND Mental capacity to consent to treatment in anorexia nervosa is a neglected area in clinical decision-making. AIMS To examine clinical and neuropsychological parameters associated with diminished mental capacity in anorexia nervosa. METHOD An explorative study was conducted in 70 adult female patients with severe anorexia nervosa. Mental capacity to consent to treatment was assess...

The presented study concerns finding an answer to the question of perceived quality relationships in family origin and personal integration, as well link between these variables among young women suffering from anorexia nervosa. aim was determine: (1) manner assessing by anorexia; (2) level their integration (as a whole relation its components, particularly trust, autonomy, sense identity); (3)...

We present a review of the Junior MARSIPAN (Management of Really Sick Patients with Anorexia Nervosa) guideline, which provides paediatricians with a framework for managing Anorexia Nervosa in the inpatient setting.

A diet with restricted energy content reduces the occurrence of cancer in animal experiments. It is not known if the underlying mechanism also exists in human beings. To determine whether cancer incidence is reduced among patients with anorexia nervosa who tend to have a low intake of energy, we carried out a retrospective cohort study of 22 654 women and 1678 men diagnosed with anorexia nervos...

Introduction The incidence of infectious complications in anorexia nervosa is uncertain. It has been suggested that leucopenia in anorexia nervosa contributes to susceptibility to infection or to immunological deficiencies (Hurd, Palumbo and Gharib, 1977). However, the meaning of isolated laboratory investigations with regard to the clinical state of the patient with anorexia nervosa is conside...

Growing evidence indicates that both positive and negative emotion potentially influence the development and maintenance of anorexia nervosa, through both positive and negative reinforcement of weight loss activities. Such reactive emotional experience may be characterized by frequent and intense fluctuations in emotion, a construct known as "emotional instability." The purpose of this study wa...

T he valid question in a discussion on the etiology of anorexia nervosa is: what caused the willful starvation that stems from the fear of fatness? It is thus important to clarify two fundamental issues at the outset: First, starvation is the cause of many of the features of anorexia nervosa, such as amenorrhea; constipation; insomnia; preoccupation with food, dieting, and shape; bulimia; food ...