Daptomycin is a cyclic anionic lipopeptide antibiotic recently approved for the treatment of complicated skin infections (Cubicin). Its function is dependent on calcium (as Ca2+). Circular dichroism spectroscopy indicated that daptomycin experienced two structural transitions: a transition upon interaction of daptomycin with Ca2+, and a further transition upon interaction with Ca2+ and the bact...

In the title complex, [Pd(CH(3)COO)(2)(C(10)H(9)N(3))], the Pd(II) ion is four-coordinated in a slightly distorted square-planar environment by two pyridine N atoms of the chelating di-2-pyridyl-amine (dpa) ligand and two O atoms from two anionic acetate ligands. The dpa ligand coordinates the Pd(II) atom in a boat conformation of the resulting chelate ring; the dihedral angle between the pyrid...

Sac family phosphoinositide phosphatases comprise an evolutionarily conserved family of enzymes in eukaryotes. Our recently determined crystal structure of the Sac phosphatase domain of yeast Sac1, the founding member of the Sac family proteins, revealed a unique conformation of the catalytic P-loop and a large positively charged groove at the catalytic site. We now report a unique mechanism fo...

Dyes wastewater produced during leather processing caused serious environmental pollution. Anionic dyes are always vital crisis in waste treatment. Removal of anionic dyes from tannery wastewater before their discharge into the environment is important for health and environment safety. The use of low-priced and biodegradable adsorbents could be a good method to minimize the environmental impac...

A distinct tadpole-shaped nanostructure characterized by a spherical head and an extended shaft was identified in a single plasmid DNA (pDNA)-based polymeric micelle. The tadpole-shaped structure was constructed by adding anionic chondroitin sulfate (CS) to the rod-shaped polyplex micelle containing a single pDNA molecule packaged by the PEG-polycation block copolymer through their electrostati...

The blood-red plutonocene complex Pu(1,3-COT'')(1,4-COT'') (4; COT''=η8 -bis(trimethylsilyl)cyclooctatetraenyl) has been synthesized by oxidation of the anionic sandwich complex Li[Pu(1,4-COT'')2 ] (3) with anhydrous cobalt(II) chloride. The first crystal structure determination of an organoplutonium(IV) complex revealed an asymmetric sandwich structure for 4 where one COT'' ring is 1,3-substit...

The title double mol-ecular salt, (C(6)H(14)N(2))[Cd(H(2)O)(6)](SO(4))(2), is an isostructure of its Mn and Co analogues. The Cd(II) atom adopts a near-regular CdO(6) octa-hedral coordination geometry. The crystal structure can be described as an alternation of cationic and anionic layers along [010], and numerous O-H⋯O and N-H⋯O hydrogen bonds are observed. No thermal anomalies corresponding t...

A series of ruthenium catalysts bearing five-membered chelating NHC architectures that exhibit very high Z-selectivity in a variety of metathesis reactions have recently been reported. It was envisioned that catalysts possessing sixmembered chelates could similarly exhibit high Z-selectivity and address limitations of this methodology. We thus prepared a number of new catalysts and systematical...

The molecular structure and orientation of interfacial water molecules at the air/water interface in the presence of soluble cationic and anionic surfactants has been characterized. We have employed vibrational sum frequency generation (VSFG) to probe the orientation of interfacial water molecules as a function of both bulk surfactant concentration and solution ion strength. The observed orderi...

The anions of PdCl(2)L(2) and Pd(OAc)(2), precursors of palladium(0) used in cross-coupling and Heck reactions, play a crucial role in these reactions. Tricoordinated anionic complexes Pd(0)L(2)Cl(-) and Pd(0)L(2)(OAc)(-) are the effective catalysts instead of the usually postulated Pd(0)L(2) complex. The anion ligated to the palladium(0) affects the kinetics of the oxidative addition to ArI as...