BACKGROUND Ovarian angiogenesis is a complex process that is regulated by a balance between pro- and anti-angiogenic factors. Physiological processes within the ovary, such as folliculogenesis, ovulation, and luteal formation are dependent upon adequate vascularization and anything that disrupts normal angiogenic processes may result in ovarian dysfunction, and possibly infertility. The objecti...

The Anti-angiogenic Activity of Phoenix dactylifera seeds methanol extract in vivo study Abstract: The aim of the study was to identify the antiangiogenic activity of Phoenix dactylifera seeds methanolic extract in vivo and the probable anti-angiogenic mechanism of action. The date seeds were extracted with methanol using cold method, the crude extract was tested on chick chorioallantoic ...

Human herpesvirus 8 (HHV-8) is a gamma-2 herpesvirus, related genetically to simian herpesvirus saimiri (HVS), the prototype virus of this subgroup of the gammaherpesvirus subfamily. HHV-8 DNA is present in all forms of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), and in most forms of multicentric Castleman's disease (MCD), especially in HIV infected individuals. Of relevance to a...

Severe fetal growth restriction (FGR) is characterized by increased placental vascular resistance resulting from aberrant angiogenesis. Interactions between endothelial cells (ECs) and the extracellular matrix (ECM) are critical to complex process of We have previously found that stromal abnormalities contribute impaired angiogenesis in severe FGR. The objective this research better characteriz...

Preeclampsia (PE) is defined as new onset hypertension after 20 weeks of gestation with evidence maternal organ or uteroplacental dysfunction proteinuria. PE a leading cause death, about 55000 deaths worldwide each year. Toxic substances that damage the vascular endothelium induce PE, resulting in liver and kidney malfunction. It crucial for obstetricians to identify early possible patients who...

BACKGROUND Commercial swine breeds in North America undergo two waves of spontaneous fetal loss; one during peri-attachment and another during mid-gestation. Although an exact mechanism for this loss is not known, deficits in vasculature at the attachment sites appear to be a major cause. We hypothesized that a balance between pro-angiogenic and anti-angiogenic factors is needed at the maternal...

Objective: The aim of this study was to investigate the possible synergistic effect curcumin on anticancer features gemcitabine prostate cancer cells. Material and Method: human adenocarcinoma cell line LNCaP used in studies. co-administration viability cells investigated by WST-1 assay. Autophagy, ubiquitin-proteasome system (UPS), unfolded protein response (UPR) death-associated proteins, and...

Angiogenesis is one of the main processes that coordinate biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute pregnancy’s physiology pathophysiology, fetal–maternal interaction. The present review outlines implications EV-mediated cr...

The incidence of breast cancer is increasing in the Western world and there is an urgent need for studies of the mechanisms of sex steroids in order to develop novel preventive strategies. Diet modifications may be among the means for breast cancer prevention. Angiogenesis, key in tumor progression, is regulated by the balance between pro- and anti-angiogenic factors, which are controlled in th...

Myeloid derived suppressor cells (MDSC) are detected at elevated levels in the peripheral blood mononuclear cells (PBMC) of human renal cell carcinoma (RCC) patients and have been shown to mediate tumor growth by promoting angiogenesis and immune suppression (Zea et al., 2005, Ko et al., 2009). Granulocytic-MDSCs (G-MDSCs), the dominant population in RCC patients, have been shown to suppress T-...