The scheduling of antifolate antitumor agents, including the new multitargeted autofolate LY231514 (MTA), with 5-fluorouracil was explored in the human MX-1 breast carcinoma and human H460 and Calu-6 non-small cell lung carcinoma xenografts to assess antitumor activity and toxicity (body weight loss). Administration of the antifolate (methotrexate, MTA, or LY309887) 6 h prior to administration ...

AN IN VITRO COMPARISON OF THE SETTING OF MTA WITH AND WITHOUT THE APPLICATION OF A MOIST COTTON PELLET Craig D. Johnson, D.D.S. Marquette University, 2010 Introduction: The purpose of this study was to compare the setting of MTA with and without the application of a moist cotton pellet. Methods: Fifty samples of MTA were mixed according to manufacturer’s instructions, placed with an amalgam car...

The aim of the present in vitro study was to investigate effects 10% and 40% citric acid (CA) on color calcium silicate–based cements (CSCs) comparison common root canal irrigants. Samples six CSCs (n = 6)—ProRoot MTA (Dentsply, Tulsa, OK, USA), Biodentine (Septodont, Saint-Maur-des-Fossés, France), Plus (Avalon Biomed Inc, by Prevest Denpro Limited, Jammu, India), Repair HP (Angelus, Londrina,...

Pemetrexed (MTA) is a multitargeted antifolate drug approved for lung cancer therapy. Clinically, supplementation with high doses of folic acid (FA) and vitamin B12 (VB12) lowers MTA cytotoxicities. An antagonistic effect of FA/VB12 on MTA efficacy has been proposed. However, patients who receive FA/VB12 show better tolerance to MTA with improved survival. The aims of this study are to investig...

On healing after periapical surgery and different retrograde root-filling materials. A clinical and histological study. Aims: The outcome from conventional endodontic therapy does not always result in a healing of the periapical area, thus leaving a remaining lesion with or without symptoms. The primary treatment alternative is a revision of the orthograde root-filling if applicable. A second t...

The purpose of this study was to evaluate whether intracoronal delivery of an apical barrier of mineral trioxide aggregate (MTA) placed ultrasonically, non-ultrasonically, or ultrasonically with the addition of an intracanal composite resin provided a better seal against bacterial leakage. A second purpose was to determine whether intracanal composite resin or gutta-percha and sealer placed aga...

The purpose of this study was to evaluate gray mineral trioxide aggregate (MTA), white MTA, and Fuji II LC cement as coronal barriers to bacterial leakage. Seventy-eight, matched, human teeth were obturated with gutta-percha. In group I, 18 pairs received a 3-mm barrier of gray or white MTA. In group II, 18 pairs received a 3-mm barrier of gray MTA or Fuji cement. Three pairs were used as posit...