To elucidate the effects of chemicals on populations of different species in the environment, efficient testing and modeling approaches are needed that consider multiple stressors and allow reliable extrapolation of responses across species. An adverse outcome pathway (AOP) is a concept that provides a framework for organizing knowledge about the progression of toxicity events across scales of ...

Structural aspects modify the structure of a program. Like behavioral aspects, structural aspects may interact and raise conflicts. While current aspect systems mostly under-consider this issue, this work addresses structural aspect interactions under the light of an iterative composition process that involves the programmer in a cycle of automatic detection of interactions and explicit, declar...

There is a long history of using both in silico and in vitro methods to predict adverse effects in humans and environmental species where toxicity data are lacking. Currently, there is a great deal of interest in applying these methods to the development of so-called 'adverse outcome pathway' (AOP) constructs. The AOP approach provides a framework for organizing information at the chemical and ...

BACKGROUND Adverse outcome pathways (AOPs) link adverse effects in individuals or populations to a molecular initiating event (MIE) that can be quantified using in vitro methods. Practical application of AOPs in chemical-specific risk assessment requires incorporation of knowledge on exposure, along with absorption, distribution, metabolism, and excretion (ADME) properties of chemicals. OBJEC...

Aspect oriented programming has been growing in popularity for several years. With many languages now available to programmers and software engineers, and extended UML with aspects, it is appropriate to place our attention on aspect orientation. In this paper we will attempt to define AOP, briefly describe several languages that implement aspects, and examine several claims of gain from the imp...

This paper presents a framework that allows plugging or unplugging Grid-related features to legacy code. Those features can, for example, transform sequential-like code to a parallel version or even a distributed version. With this approach scientists could develop their code as they are used to, that is, they could spent their time programming as they are used to instead of learning new progra...

In AspectJ-like languages, there are several different kinds of advice declarations, which are specified by using advice modifiers such as before and after returning. This makes semantics of advice complicated and also makes advice declarations less reusable since advice modifiers are not parameterized unlike pointcuts. We propose a simpler join point model and an experimental AOP language call...

ABSTRACT The su ess of aspe t-oriented programming (AOP) raises and falls with user-friendly tool support. With Aspe tJ1 the rst omplete and powerful language extension for AOP has been reated. With this paper we intend to extend the Aspe tJ approa h to C/C++. We will present and dis uss a proposal for a set of language extensions we all Aspe tC++ to fa ilitate aspe t-oriented programming with ...

Refactoring has become a well-known technique for improving the code in a way that preserves behavior. The application of refactorings during development process of an object oriented or procedure oriented software improves the design and therefore the quality of software. During the evolution of software it is a requirement to refactor them in order to make it more compatible and flexible with...

In [9] we defined the concept of agent oriented programming (AOP), which can be viewed as a specialization of object oriented programming (OOP). AOP views objects as agents with mental state, and, in the spirit of speech act theory, identifies a number of message types informing, requesting, offering, and so on. AOP is a general framework. In this paper we present a specific and simple language...