BACKGROUND AND OBJECTIVE It is unclear whether the proportion of infants with a disorder of sex development who are raised as male or female has changed over time. The temporal trends in sex assignment of affected cases entered in the International Disorder of Sex Development (I-DSD) Registry were studied. METHODS Cases of disorders of sex development reported as partial androgen insensitivit...

Androgen insensitivity syndrome (AIS) also called testicular feminizing is a rare X linked disorder of sexual differentiation caused by mutation in the androgen receptor (AR) gene, which located on chromosome (Xq11-q12). In reported cases, individuals with complete (CAIS) presented female appearance and normal breast development, absence uterus ovaries, bilateral undescended testis, elevated te...