Cell division, intuitively, is often dependent upon increases in cellular mass and volume. Less obvious is the reciprocal regulation of growth by the cell division cycle. In budding yeast, this link is mediated by the cell-cycle-dependent polarization of actin.

In this issue of Neuron, Ben-Yaacov et al. (2017) dissect the interaction between AMPA receptors and auxiliary (TARP) subunits, revealing essential roles for the receptor transmembrane and cytoplasmic domains, as well as for the TARP extracellular EX2 loop.