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OBITUARY G. E. Gask, C.M.G., D.S.O., F.R.C.S. ....193 Sir Lenthal Cheatle, K.C.B., C.V.O., F.R.C.S. 194 J. H. Rawlinson, F.R.C.S.Ed. ............ 194 W. J. Logie, M.B. ................... 195 C. R. Worthington, B.ch. ..........I..... 195 E. J. Davis-Taylor, M.B. ..............195 C. W. Gurd, M.B. ................... 195 LEADING ARTICLES The Old Minister and the New ........ 175 The B,2 Group of...
The recent experimental observation of collective rotational bands up to I > 60h̄ in 175Hf presents theoretical challenges. It is shown here that total Routhian surface calculations are able to explain the yrast high-spin behavior, with collective oblate states favored at I ∼ 35h̄ and strongly deformed prolate states at the highest spins. The collective oblate rotation terminates in noncollective...
It is estimated that one-third part of the world population is infected with the tubercle bacillus. While only a small percentage of infected individuals will develop clinical tuberculosis, each year there are approximately eight million new cases and two million deaths. Mycobacterium tuberculosis is thus responsible for more human mortality than any other single microbial species. The goals of...
INTRODUCTION Recent studies have demonstrated the role of the interleukin 28B (IL28B) polymorphisms in predicting treatment induced and spontaneous clearance from Hepatitis C virus (HCV) infection, suggesting the possibility of tailored therapy in HCV infected patients. Genome-wide association studies have shown that single nucleotide polymorphisms (SNPs) near IL 28B gene on chromosome 19 are s...
The genomes of the aerobic methanotrophs "Methyloterricola oryzae" strain 73aT and Methylomagnum ishizawai strain 175 were sequenced. Both strains were isolated from rice plants. Methyloterricola oryzae strain 73aT represents the first isolate of rice paddy cluster I, and strain 175 is the second representative of the recently described genus Methylomagnum.
PURPOSE To establish the maximum tolerated dose of lonafarnib, a novel farnesyltransferase inhibitor, in combination with paclitaxel in patients with solid tumors and to characterize the safety, tolerability, dose-limiting toxicity, and pharmacokinetics of this combination regimen. EXPERIMENTAL DESIGN In a Phase I trial, lonafarnib was administered p.o., twice daily (b.i.d.) on continuously s...
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