PURPOSE To study the pharmacokinetics and dose proportionality of moxidectin in beagle dogs experimentally infected with the filarial parasite Brugia pahangi, and to evaluate and compare the results obtained from population pharmacokinetic analysis and individual compartmental analysis. METHOD Thirty-six infected dogs were selected and randomly allocated into six treatment groups of six dogs ...

The impact of age and gender on Ochratoxin A (OTA) distribution in kidney and liver were studied. OTA was quantified in kidney and liver of young and mature rats of both sexes. Data was fit simultaneously using the population approach with NONMEM program. Fed and fasted mature males showed a 30% decrease and an 11% increase in relative bioavailability, respectively, in comparison with the rest ...

This qualitative study delineates motives for residential mobility, describes dynamics between the elder and family members during the move decision process, and locates the move decision within ecological layers of the aging context. Interviews were conducted with 30 individuals and couples (ages 60-87) who experienced a community-based move within the past year, and with 14 extended family me...

The ability to create lasting, trust-based friendships makes it possible for humans to form large and coherent groups. The recent literature on the evolution of sociality and on the network dynamics of human societies suggests that large human groups have a layered structure generated by emotionally supported social relationships. There are also gender differences in adult social style which ma...

The model suggests that there are six constituents to moral identity arranged in two layers. The first layer, at the left edge of the figure, is constituted of enduring personality and social characteristics that form the foundation for much of child and adolescent development. The kinds of personality and social characteristics in this layer change slowly and may be outside of children’s and a...

BACKGROUND The musculoskeletal disorders in working population represent one of the most worrying work-related health issues at the present time and although the very great majority of available data on the subject focus on musculoskeletal disorders defined by anatomical site, a growing number of studies indicate the low prevalence of disorders strictly confined to a specific anatomical site. T...

introduction: medical undergraduates usually understand and memorize anatomical course material with difficulty. also, the current text books and atlases of anatomy and histology do not fulfill all the learning needs of the undergraduates. therefore, it is necessary to consider the role of internet websites and computer programs (i.e. the role of electronic learning) in teaching. the present re...

absracta rare variant of ansa cervicalis was discovered during dissection of the neck in amale cadaver. the superior root of the ansa cervicalis was formed by the c1 ventralramus. it accompanied with the vagus nerve in place of the hypoglossal nerve and descendedinto the carotid sheath with it. moreover the c1 ventral ramus formed fromthe sheath and joined the inferior root from c2 and c3 ventr...

UNLABELLED Dextroscope three-dimensional (3D) imaging has been extensively applied for generation of virtual reality (VR) workspaces for in neurosurgery and laparoscopy, though few applications in orthopedic surgery have been reported. Patients undergoing surgery for periarticular tumors (n = 10) from Oct. 2008 to Jun. 2010 were enrolled and presurgically subjected to computed tomography (CT), ...

Desmoncus orthacanthos is a Neotropical climbing palm that resembles rattan and therefore has similar potential applications. The genus Desmoncus (subfamily Arecoideae, subtribe Bactridinae) is distributed throughout the Americas, from Veracruz, Mexico, to Brazil and Bolivia. The anatomical characteristics of its support tissue have not been thoroughly studied, although some observations from C...