نتایج جستجو برای: anastrozole

تعداد نتایج: 712  

Journal: :Current medical research and opinion 2002
K Mokbel G Singh-Ranger

This article reviews the recent findings of the IBIS-1 and ATAC trials regarding the role of tamoxifen and anastrozole in the chemoprevention of breast cancer. It also emphasises the need to individualise chemoprevention strategies, and to identify high-risk women who are most likely to develop oestrogen receptor (ER)-positive breast cancer. The prevention of ER-negative disease requires furthe...

Journal: :Clinical chemistry 2012
Anthony Howell

Featured Article: Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancer. Howell A, Cuzick J, Baum M, Buzdar A, Dowsett M, Forbes JF, ATAC Trialists’ Group. Lancet 2005;365: 60 –2. Aromatase inhibitors block the enzyme aromatase, which is responsible for conversion of the adrenal derived precursor, androstenedio...

Journal: :Endocrine-related cancer 1999
M Baum

The value of endocrine treatment of early breast cancer has been illustrated by the antioestrogen, tamoxifen, which has now been available for nearly 30 years. However, if the recognised side effects and pharmacological properties of tamoxifen are taken into consideration, it is possible that other endocrine treatments that are now available can provide equal or superior efficacy, along with im...

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003
Kala Visvanathan Nancy E Davidson

The aromatase inhibitors are regarded as standard approaches to first- or second-line endocrine therapy in women with hormone-responsive metastatic breast cancer. Their efficacy and apparent lack of toxicity have led to their evaluation as adjuvant therapy. Although initial results with these agents in early breast cancer are promising, our collective long-term experience documenting tamoxifen'...

2012
Virginija Jazbutyte Jan Stumpner Andreas Redel Johan M. Lorenzen Norbert Roewer Thomas Thum Franz Kehl

The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. We hypothesized that endogenous estrogens play a role as mediators of desflurane-induced preconditioning against myocardial infarction. In this study, we tested the hypothesis that desflurane effects local estrogen synthesis by modulating enzym...

Journal: :Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2009
Ignasi Tusquets Trías de Bes Sònia Servitja Tormo Joan Albanell Mestres

Women are at considerable risk of recurrence in the first few years following initial treatment for early breast cancer. To reduce the risk of recurrence, including distant metastases, those with hormone-sensitive breast cancer receive adjuvant endocrine treatment. Lymph node metastases are a predictor of high risk of early recurrence and distant metastases; however, a significant number of wom...

Journal: :Journal of the National Cancer Institute 2007
Mitch Dowsett Ian E Smith Stephen R Ebbs J Michael Dixon Anthony Skene Roger A'Hern Janine Salter Simone Detre Margaret Hills Geraldine Walsh

Tumor expression of the proliferation antigen Ki67 is widely used to assess the prognosis of cancer patients. A change in the expression of Ki67 after short-term exposure of patients to therapeutic agents is frequently used as a pharmacodynamic marker of efficacy, particularly among breast cancer patients before undergoing surgery. To determine the clinical significance of the level of tumor ce...

Journal: :Steroids 2011
Anita K Dunbier Helen Anderson Zara Ghazoui Janine Salter Joel S Parker Charles M Perou Ian E Smith Mitch Dowsett

Considerable heterogeneity exists amongst oestrogen receptor positive (ER+ve) breast cancer in both its molecular profile and response to therapy. Attempts to better define variation amongst breast tumours have led to the definition of four main "intrinsic" subtypes of breast cancer with two of these classes, Luminal A and B, composed almost entirely of ER+ve cancers. In this study we set out t...

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