The trafficking of the amyloid precursor protein (APP) is critical for controlling the generation of the toxic A beta peptide that is central to amyloid formation in Alzheimer's disease. A new study reveals a key role for the AP4 adaptor protein complex in the Golgi-to-endosome trafficking of APP.

Alzheimer’s disease (AD) is today the most common form of dementia. It is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. APP belongs to a conser...

β-amyloid peptides (Aβ) are generated in intracellular compartments of neurons and secreted to form cytotoxic fibrils plaques. Dysfunctional membrane trafficking contributes aberrant Aβ production Alzheimer's disease. Endosomes represent one the major sites for recently Golgi has re-emerged also as a location amyloid precursor protein (APP) processing production. Based on recent findings, here ...