نتایج جستجو برای: amylin
تعداد نتایج: 1046 فیلتر نتایج به سال:
OBJECTIVE In response to hyperglycemia, beta-cells release insulin and C-peptide, as well as islet amyloid pancreatic polypeptide, which is involved in glucose homeostasis. After successful pancreas-kidney transplantation (PKT), type 1 diabetic patients may revert to a nondiabetic metabolism without exogenous insulin therapy and re-secrete all beta-cell hormones. RESEARCH DESIGN AND METHODS U...
243 Introduction 474 Discussion 1165 Non standard abbreviations: AMY, amylin receptor phenotype; CGRP, calcitonin gene-related peptide; CLR, calcitonin receptor-like receptor; CT, calcitonin; CTR, calcitonin receptor; GPCR, G protein-coupled receptor; HA, haemagglutinin epitope tag; hCT, human calcitonin; RAMP, receptor activity modifying protein; rAmy, rat amylin; sCT, salmon calcitonin; TMD, ...
Corresponding Author: Alan B. Schorr, D.O., 380 Middletown Boulevard, Suite 710, Langhorne, PA 19047; email address [email protected] The combination of insulin and an amylin mimetic is an option for diabetes treatment.1,2 The effectiveness of this modality has been established, but there is a limited amount of literature regarding the use of this combined treatment via continuous subcutaneo...
This study aims to elucidate the mechanism behind the potent weight loss induced by dual amylin and calcitonin receptor agonists (DACRA) through comparison of the novel DACRA KBP-088 with the amylinomimetic davalintide with regard to in vitro receptor pharmacology and in vivo efficacy on food intake and body weight. KBP-088 and davalintide were tested for their ability to activate the amylin an...
Leptin enhances insulin sensitivity in addition to reducing food intake and body weight. Recently, amylin, a pancreatic β-cell-derived hormone, was shown to restore a weight-reducing effect of leptin in leptin-resistant diet-induced obesity. However, whether amylin improves the effect of leptin on insulin sensitivity in diet-induced obesity is unclear. Diet-induced obese (DIO) mice were infused...
The structural characterization of amyloid fibers is one of the most investigated areas in structural biology. Recently, protofibril models for amylin, i.e., the 37-residue human islet amyloid polypeptide or hIAPP were suggested by two groups based on NMR (Biochemistry 2007, 46, 13505-13522) and X-ray (Protein Sci. 2008, 17, 1467-1474) techniques. However, there are significant differences in t...
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