نتایج جستجو برای: ampk pathway

تعداد نتایج: 319504  

Journal: :Neuron 2013
Georges Mairet-Coello Julien Courchet Simon Pieraut Virginie Courchet Anton Maximov Franck Polleux

Amyloid-β 1-42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and hippocampal neurons and might play a role in early stages of Alzheimer's disease (AD) progression. Recent results suggested that Aβ42 oligomers trigger activation of AMP-activated kinase (AMPK), and its activation is increased in the brain of patients with AD. We show that increased intracellular calcium [Ca²⁺](i) indu...

Journal: :Phytotherapy research : PTR 2009
Jin-Taek Hwang Myoung-Su Lee Hyun-Jin Kim Mi-Jeong Sung Hye Young Kim Myung Sunny Kim Dae Young Kwon

Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte differentiation. This inhibitory effect of ginsenosi...

Journal: :Molecular pharmacology 2006
Franck Rencurel Marc Foretz Michel R Kaufmann Deborah Stroka Renate Looser Isabelle Leclerc Gabriela da Silva Xavier Guy A Rutter Benoit Viollet Urs A Meyer

Our previous studies have suggested a role for AMP-activated protein kinase (AMPK) in the induction of CYP2B6 by phenobarbital (PB) in hepatoma-derived cells (Rencurel et al., 2005). In this study, we showed in primary human hepatocytes that: 1) 5'-phosphoribosyl-5-aminoimidazol-4-carboxamide 1-beta-d-ribofuranoside and the biguanide metformin, known activators of AMPK, dose-dependently increas...

Journal: :International journal of clinical and experimental pathology 2014
Liang Hu Lu Zhou Xiaowei Wu Chao Liu Yue Fan Qingping Li

OBJECTIVE AMP-activated protein kinase (AMPK) is an important regulator of multiple cellular pathways in the setting of energetic stress. Whether AMPK plays a critical role in hypoxic preconditioning (HPC), protecting cardiomyocytes against hypoxia reoxygenation (H/R) injury remains uncertain. METHODS H9c2 cells were preconditioned by exposing to 10 min of hypoxia and 30 min of reoxygenation....

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Guifen Qiang Xiuying Yang Lili Shi Hengai Zhang Bainian Chen Yan Zhao Mian Zu Dan Zhou Jing Guo Haiguang Yang Li Zhang Guanhua Du

BACKGROUND/AIMS Diabetes mellitus (DM) characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic compound isolated from the root of Salvia miltiorrhiza Bunge, which is a traditional Chinese medicine widely used to treat cardiovascular diseases. However, little is known about its antidiabetic effect. Our study aimed t...

2015
Hu-Ping Deng Jia-Ke Chai Chuan-An Shen Xi-Bo Zhang Li Ma Tian-Jun Sun Qing-Gang Hu Yun-Fei Chi Ning Dong

While insulin is an anabolic hormone, AMP-activated protein kinase (AMPK) is not only a key energy regulator, but it can also control substrate metabolism directly by inducing skeletal muscle protein degradation. The hypothesis of the present study was that insulin inhibits AMPK and thus down-regulates the expression of the ubiquitin E3 ligases, muscle atrophy F-box (MAFbx) and muscle RING fing...

Journal: :Cell 2003
Ken Inoki Tianqing Zhu Kun-Liang Guan

Mutations in either the TSC1 or TSC2 tumor suppressor gene are responsible for Tuberous Sclerosis Complex. The gene products of TSC1 and TSC2 form a functional complex and inhibit the phosphorylation of S6K and 4EBP1, two key regulators of translation. Here, we describe that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway. Under en...

2017
Wei Xing Lei Yang Yue Peng Qianlu Wang Min Gao Mingshi Yang Xianzhong Xiao

Sepsis-led mitochondrial dysfunction has become a critical pathophysiological procedure in sepsis. Since ginsenosides have been applied in the treatment of mitochondrial dysfunction, ginsenoside Rg3 was employed to study its effects on the mitochondrial dysfunction induced by sepsis. The apoptosis rate, oxygen consumption rate (OCR), reactive oxygen species (ROS), antioxidant glutathione (GSH) ...

2014
Shingo Matsuyama Masataka Moriuchi Mary Ann Suico Shuichiro Yano Saori Morino-Koga Tsuyoshi Shuto Kunitoshi Yamanaka Tatsuya Kondo Eiichi Araki Hirofumi Kai

Electrical current at physiological strength has been applied as a therapeutic approach for various diseases. Several of our works showed that mild electrical stimulation (MES) at 0.1-ms pulse width has positive impact on organisms. But despite the growing evidence of the beneficial effects of MES, its effects on individual animals and the molecular underpinnings are poorly understood and rarel...

2015
CONG FAN YUNSHAN WANG ZIMING LIU YING SUN XIUWEN WANG GUANGWEI WEI JUNMIN WEI

Metformin, a widely prescribed antidiabetic drug, has previously been shown to lower the risk of certain types of cancer, including that of breast cancer, and to improve prognosis. Its anticancer effects, which are mediated by the activation of AMP-activated protein kinase (AMPK), have become notable. The Sonic hedgehog (Shh) signaling pathway is involved in changes in mammary ducts and maligna...

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