نتایج جستجو برای: amacr
تعداد نتایج: 195 فیلتر نتایج به سال:
half of all prostate cancers in the Western countries harbor gene fusions that involve regulatory sequences of the androgen receptor (AR)-responsive genes (predominantly TMPRSS2) and protein coding sequences of nuclear transcription factors of the ETS gene family (predominantly ERG). This leads to unscheduled androgen-dependent expression ofETS-related transcription factors in tumor cell-specif...
Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC-K) is an unusual renal tumor. It is important to increase the recognition of MTSCC-K and improve the level of clinical diagnosis. The current study presents a case of MTSCC-K with clinical, imaging and pathological examination. A 60-year-old female presented to the First Hospital of Jilin University suffering from lumbodorsalgia o...
The disease concept of clear cell (tubulo) papillary renal cell carcinoma (CCP-RCC) as a distinct subtype of renal cell carcinoma has been recently established. First described in the setting of end stage renal disease, this tumor type is more frequently recognized and encountered in a sporadic setting. In this article, we provide an overview of the recent understanding of this tumor. Macroscop...
PURPOSE About 50% of prostate cancers have TMPRSS2-ERG fusions with concurrent ERG overexpression. The aim of this study was to determine whether clinical differences exist between ERG-positive and ERG-negative cancers in surgically treated patients not exposed to antihormonal therapy. A secondary aim was to search for differences between these tumor classes. EXPERIMENTAL DESIGN A tissue micr...
• The use of immunohistochemistry for basal cell markers and AMACR for the diagnosis of limited adenocarcinoma of the prostate should be used as an adjunct to the H&E diagnosis as there is false positive and negative staining with these markers. • Examples of labeling of prostate adenocarcinoma with basal cell markers include: aberrant scattered HMWCK staining of cancer cells; rarely the retent...
micropapillary variant of urothelial carcinoma (uc) of the bladder is an aggressive tumour, comprising 0.6-6% of all uc. it generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional uc. we report the case of a 58-year-old man who presented with macroscopic haematuria. the patient was diagnosed with high-grade urothelial carcinom...
Tubulocystic renal cell carcinoma (TCRCC) is a relatively recently recognized renal neoplasm that exhibits distinct macroscopic and microscopic characteristics. Herein, we report a comprehensive study of pure TCRCC in 9 patients in which we evaluated the clinical, pathological, immunohistochemical and molecular characteristics of this disease. The patients’ ages ranged from 21 to 46 years (mean...
Prostate cancer (PCa) is the most commonly diagnosed neoplasm and the second leading cause of cancer-related deaths in men. Acquisition of resistance to conventional therapy is a major problem for PCa patient management. Several mechanisms have been described to promote therapy resistance in PCa, such as androgen receptor (AR) activation, epithelial-to-mesenchymal transition (EMT), acquisition ...
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