نتایج جستجو برای: als inhibitors

تعداد نتایج: 215479  

A. Saidi, M. Mirzaei

In This research, gold nanoparticles were synthesized and functionalized by the antibody of aflatoxins. The quenching of the fluorescence of excitation emission matrices (EEM) of two type of aflatoxins (B1, G1), provoked by the gold nanoparticles, was studied by principal component analysis (PCA) and multivariate curve resolution with alternating least squares (MCR-ALS). These aflatoxins show q...

Journal: :Emergency medicine journal : EMJ 2005
P Gilligan C Bhatarcharjee G Knight M Smith D Hegarty A Shenton F Todd P Bradley

BACKGROUND AND OBJECTIVES In many emergency departments advanced life support (ALS) trained nurses do not assume a lead role in advanced resuscitation. This study investigated whether emergency nurses with previous ALS training provided good team leadership in a simulated cardiac arrest situation. METHODS A prospective study was conducted at five emergency departments and one nurses' associat...

Journal: :JAMA neurology 2014
Yuichi Riku Hirohisa Watanabe Mari Yoshida Shinsui Tatsumi Maya Mimuro Yasushi Iwasaki Masahisa Katsuno Yohei Iguchi Michihito Masuda Jo Senda Shinsuke Ishigaki Tsuyoshi Udagawa Gen Sobue

IMPORTANCE TAR DNA-binding protein of 43 kDa (TDP-43) plays a major role in the pathogenesis of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Although a pathological continuity between FTLD and ALS has been suggested, the neuropathological changes of the lower motor neuron (LMN) systems have not been assessed in TDP-43-associated FTLD (FTLD-TDP), to our knowl...

Journal: :Zeitschrift für Entwicklungspsychologie und Pädagogische Psychologie 2004

2014
Seong-il Oh Aram Park Hee-Jin Kim Ki-Wook Oh Hojin Choi Min-Jung Kwon Chang-Seok Ki Hee-Tae Kim Seung Hyun Kim

BACKGROUND Cognitive impairment is associated with a negative prognosis in amyotrophic lateral sclerosis (ALS), as well as with clinical specificity. We investigate neuropsychological function in ALS patients without known genetic mutations in a Korean tertiary clinic. METHODS Three hundred and eighteen patients were enrolled in a prospective longitudinal cohort from September 2008 to Februar...

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurogenic progressive disease that leads to muscle atrophy. The purpose of this study was to evaluate pulmonary function test (PFT) in patients with ALS and its correlation with ASL symptoms. Materials and Methods: This cross-sectional study was performed on 32 ALS patients at Ghaem Hospital, Mashhad...

2009
Fang Fang

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. The causes of ALS remain largely unknown more than 140 years after the disease was first described. The overall aims of this thesis were to describe t...

2015
Venkateswaran Rajagopalan Erik P. Pioro

Even though neuroimaging and clinical studies indicate that amyotrophic lateral sclerosis (ALS) manifests with distinct clinical phenotypes, no objective test exists to assess upper motor degeneration in ALS. There is great interest in identifying biomarkers of ALS to allow earlier diagnosis and to recognize disease subtypes. Current quantitative neuroimaging techniques such as T2 relaxometry a...

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