OBJECTIVE The primary disadvantage of high-potency benzodiazepine treatment for panic disorder is the difficulty of discontinuing the treatment. During treatment discontinuation, new symptoms may emerge and anxiety may return, preventing many patients from successfully discontinuing their treatment. In this controlled, randomized trial the authors investigated the efficacy of a cognitive-behavi...

We would like to thank Koniari et al.1 for the interest demonstrated in our manuscript. We have reported the case of an 85-year-old male who developed type 1 Kounis syndrome (coronary spasm) after administration of ciprofloxacin.2 The authors pointed out the potential role of the combined effect of the drugs the patient was taking (hydroxyzine and alprazolam). Indeed, they cited case reports of...

BACKGROUND Symptomatic paroxysmal hypertension without significantly elevated catecholamine concentrations and with no evidence of an underlying adrenal tumor is known as pseudopheochromocytoma. METHODS We describe the case of a female patient with paroxysmal hypertensive crises accompanied by headache, vertigo, tachycardia, nausea and altered mental status. Previously, she was treated for a ...

Intravenous drug abuse unfortunately remains an extremely common problem worldwide, accounting for innumerable medical issues ranging from the transmission of human immunodeficiency virus (HIV) and other blood-borne diseases to skin necrosis to vasculitis to death [1]. We present a case of intra-arterial injection of alprazolam into the right femoral artery resulting in microembolization, acute...

  Abstract   Introduction: Inflammation and wear debris may be responsible for bone lysis   and subsequent lost in aseptic arthroplasty. Prostaglandin E2, platelet activating factor,   and histamine are important mediators of inflammatory cells. We studied   histopathological changes of cement-bone interface after using specific antagonists   of these mediators.   Methods: Left and right tibiae...

A doença de coronavírus 2019 (COVID-19) causou impactos na saúde mental da população e vários estudos mostraram um aumento nas taxas ansiedade, depressão, insônia estresse durante o período pandêmico. Os benzodiazepínicos (BZDs) têm sido comumente prescritos para tratamento ansiedade últimas décadas. Assim, a pesquisa buscou realizar uma análise comparativa das vendas BZDs antes pandemia Covid-...