Thalassaemia is a disease of abnormal development red blood cells which manifests as anaemia. This chronic may cause mental, social, financial burdens on the families, care givers and also health system. To assess quality life (QOL) caregivers thalassaemic children to identify predictors their physical mental health. Institution based descriptive cross-sectional study conducted in Control Unit ...

background: the most important problem in regular transfusion dependent β-thalassemia major is cardiac dysfunction due to iron deposition in it. the aim of this study was to evaluate correlation between serum ferritin levels and cardiac function in β-thalassemia major in mofid hospital. materials and methods: there were 112 β-thalassemia patients with a mean age of 13.55± 6.12 years, of whom 49...

in Hong Kong. Prenatal Diag 1997; 17:733-6. 5. Chan AY, So CK, Chan LC. Comparison of the HbH inclusion test and a PCR test in routine screening for alpha thalassaemia in Hong Kong. J Clin Pathol 1996; 49:411-3. 6. British Committee for Standards in Haematology. Guideline: The laboratory diagnosis of haemoglobinopathies. Br J Haematol 1998; 101:783-92. 7. Lafferty J, Crowther M, Waye JS, Chui D...

Two sibs with non-deletional alpha thalassaemia and mental retardation (ATR-X) have been ascertained showing variable neurological features. The proband had a complex neurological picture with recurrent apnoea, complex partial seizures, and prolonged periods of semiconsciousness between 12 and 17 months of age. Episodes of spontaneous laughter were also a feature. An EEG was initially normal. H...

BACKGROUND The medical and economic problem of thalassaemia are considered to be a vast public health problem in the thalassaemia belt countries, emphasizing more on prenatal diagnosis as the solution of the problem. METHODS A cross-sectional descriptive study was conducted in the Institute of Haematology & Transfusion Medicine located in Medical College, Kolkata, India to assess the socio-de...

The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells-from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. ...