Cell cultures derived from trabecular meshworks of human and bovine eyes and from bovine vascular endothelia were incubated at 37 degrees C for 1 hr with ethacrynic acid (ECA, 0.1-0.5 mmol/l) dissolved in culture medium. At 2 hr after the initial exposure, ECA at concentrations up to 0.4 mmol/l induced a reversible alteration in cell shape in all three cell types that was coincident with a chan...

To understand the structure of molecules, various computational methodologies have been extensively investigated such as the Voronoi diagram of the centers of atoms in molecule and the power diagram for the weighted points where the weights are related to the radii of the atoms. For a more improved efficiency, constructs like an α-shape or a weighted α-shape have been developed and used frequen...

Edwin M. Knorr, Raymond T. Ng, David L. Shilvock Department of Computer Science University of British Columbia Vancouver, B.C., V6T 1Z4, Canada fknorr,[email protected] Abstract This paper describes a new approach to knowledge discovery among spatial objects|namely that of partial boundary shape matching. Our focus is on mining spatial data, whereby many objects called features (represented as pol...

Computational anatomy (CA) is the mathematical study of anatomy I in I = I(alpha) o G, an orbit under groups of diffeomorphisms (i.e., smooth invertible mappings) g in G of anatomical exemplars I(alpha) in I. The observable images are the output of medical imaging devices. There are three components that CA examines: (i) constructions of the anatomical submanifolds, (ii) comparison of the anato...

During Caenorhabditis elegans development, the embryo acquires its vermiform shape due to changes in the shape of epithelial cells, a process that requires an apically localized actin cytoskeleton. We show that SMA-1, an ortholog of beta(H)-spectrin required for normal morphogenesis, localizes to the apical membrane of epithelial cells when these cells are rapidly elongating. In spc-1 alpha-spe...

Individual tree crown segmentation from Airborne Laser Scanning data is a nodal problem in forest remote sensing. Focusing on single layered spruce and fir dominated coniferous forests, this article addresses the problem of directly estimating 3D segment shape uncertainty (i.e., without field/reference surveys), using a probabilistic approach. First, a coarse segmentation (marker controlled wat...

The problem of calculating the electric polarizability tensor alpha(e) of objects of arbitrary shape has been reformulated in terms of path integration and implemented computationally. The method simultaneously yields the electrostatic capacity C and the equilibrium charge density. These functionals of particle shape are important in many materials science applications, including the conductivi...

Nodes along the boundaries of a Wireless Sensor Network (WSN) play some other important roles in addition to their routine tasks. A prior knowledge of the WSN boundaries can effectively be utilized in numerous WSN aspects pertaining to mobile events, mobile nodes, geographic routing, shape and coverage maintenance, barrier coverage etc. In this paper, we present a localized method based on actu...

Cofilin is a regulator of actin filament dynamics. We studied whether during platelet activation Rho kinase stimulates LIM kinase (LIMK) leading to subsequent phosphorylation and inactivation of cofilin. Platelet shape change and aggregation/secretion were induced by low and high concentrations of thrombin, respectively. We found that during these platelet responses Rho kinase activation was re...